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Huperzine A for Alzheimer's disease

Overview of attention for article published in this source, April 2008
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2 news outlets
1 blog
1 tweeter
2 Wikipedia pages


62 Dimensions

Readers on

126 Mendeley
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Huperzine A for Alzheimer's disease
Published by
John Wiley & Sons, Ltd, April 2008
DOI 10.1002/14651858.cd005592.pub2
Pubmed ID

Li, Jun, Wu, Hong Mei, Zhou, Rongle L, Liu, Guan Jian, Dong, Bi Rong


Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD. Cholinesterase inhibitors may block the degradation of acetylcholine, thus increasing the efficacy of the remaining cholinergic neurons. Huperzine A is a linearly competitive, reversible inhibitor of acetyl cholinesterase that is said to have both central and peripheral activity with the ability to protect cells against hydrogen peroxide, beta-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These properties might qualify Huperzine A as a promising agent for treating dementia (including AD).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Germany 2 2%
Spain 1 <1%
Unknown 120 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 21%
Student > Ph. D. Student 22 17%
Student > Master 19 15%
Student > Bachelor 15 12%
Unspecified 12 10%
Other 31 25%
Readers by discipline Count As %
Medicine and Dentistry 34 27%
Unspecified 20 16%
Psychology 18 14%
Nursing and Health Professions 12 10%
Social Sciences 10 8%
Other 32 25%