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Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Overview of attention for article published in Trends in Cancer, November 2016
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Mentioned by

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5 tweeters

Citations

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1 Dimensions

Readers on

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13 Mendeley
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Title
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Published in
Trends in Cancer, November 2016
DOI 10.1016/j.trecan.2016.10.009
Pubmed ID
Authors

Xiaonan Zhang, Angelo De Milito, Asuman Demiroglu-Zergeroglu, Joachim Gullbo, Padraig D’Arcy, Stig Linder

Abstract

The presence of quiescent cell populations in solid tumors represents a major challenge for disease eradication. Such cells are generally present in poorly vascularized tumor areas, show limited sensitivity to traditional chemotherapeutical drugs, and tend to resume proliferation, resulting in tumor reseeding and growth. There is growing recognition of the importance of developing therapies that target these quiescent cell populations to achieve long-lasting remission. Recent studies have shown that the combination of hypoxia and reduced nutrient availability in poorly vascularized areas results in limited tumor metabolic plasticity coupled with an increased sensitivity to perturbations in mitochondrial flux. Targeting of mitochondrial bioenergetics in these quiescent cell tumor populations may enable tumor eradication and improve the prognosis of patients with cancer.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 38%
Researcher 3 23%
Other 1 8%
Student > Bachelor 1 8%
Student > Ph. D. Student 1 8%
Other 2 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 46%
Agricultural and Biological Sciences 3 23%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Business, Management and Accounting 1 8%
Unspecified 1 8%
Other 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2018.
All research outputs
#6,867,672
of 11,477,928 outputs
Outputs from Trends in Cancer
#245
of 272 outputs
Outputs of similar age
#160,715
of 320,075 outputs
Outputs of similar age from Trends in Cancer
#22
of 24 outputs
Altmetric has tracked 11,477,928 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 272 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,075 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.