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Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Overview of attention for article published in Trends in Cancer, November 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)

Mentioned by

twitter
6 tweeters

Readers on

mendeley
12 Mendeley
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Title
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Published in
Trends in Cancer, November 2016
DOI 10.1016/j.trecan.2016.10.009
Pubmed ID
Authors

Xiaonan Zhang, Angelo De Milito, Asuman Demiroglu-Zergeroglu, Joachim Gullbo, Padraig D’Arcy, Stig Linder

Abstract

The presence of quiescent cell populations in solid tumors represents a major challenge for disease eradication. Such cells are generally present in poorly vascularized tumor areas, show limited sensitivity to traditional chemotherapeutical drugs, and tend to resume proliferation, resulting in tumor reseeding and growth. There is growing recognition of the importance of developing therapies that target these quiescent cell populations to achieve long-lasting remission. Recent studies have shown that the combination of hypoxia and reduced nutrient availability in poorly vascularized areas results in limited tumor metabolic plasticity coupled with an increased sensitivity to perturbations in mitochondrial flux. Targeting of mitochondrial bioenergetics in these quiescent cell tumor populations may enable tumor eradication and improve the prognosis of patients with cancer.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 33%
Student > Ph. D. Student 2 17%
Unspecified 2 17%
Professor 1 8%
Student > Bachelor 1 8%
Other 2 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 42%
Unspecified 3 25%
Agricultural and Biological Sciences 3 25%
Business, Management and Accounting 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2018.
All research outputs
#4,787,785
of 9,723,837 outputs
Outputs from Trends in Cancer
#216
of 251 outputs
Outputs of similar age
#139,803
of 315,856 outputs
Outputs of similar age from Trends in Cancer
#21
of 24 outputs
Altmetric has tracked 9,723,837 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,856 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.