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CAR T Cell Therapy for Solid Tumors

Overview of attention for article published in Annual Review of Medicine, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 684)
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

news
8 news outlets
twitter
95 tweeters

Citations

dimensions_citation
118 Dimensions

Readers on

mendeley
266 Mendeley

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Summary News Twitter Dimensions citations
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Title
CAR T Cell Therapy for Solid Tumors
Published in
Annual Review of Medicine, January 2017
DOI 10.1146/annurev-med-062315-120245
Pubmed ID
27860544
Authors

Kheng Newick, Shaun O'Brien, Edmund Moon, Steven M. Albelda

Abstract

The field of cancer immunotherapy has been re-energized by the application of chimeric antigen receptor (CAR) T cell therapy in cancers. These CAR T cells are engineered to express synthetic receptors that redirect polyclonal T cells to surface antigens for subsequent tumor elimination. Many CARs are designed with elements that augment T cell persistence and activity. To date, CAR T cells have demonstrated tremendous success in eradicating hematologic malignancies (e.g., CD19 CARs in leukemias). However, this success has yet to be extrapolated to solid tumors, and the reasons for this are being actively investigated. We characterize some of the challenges that CAR T cells have to surmount in the solid tumor microenvironment and new approaches that are being considered to overcome these hurdles. Expected final online publication date for the Annual Review of Medicine Volume 68 is January 14, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Twitter Demographics

The data shown below were collected from the profiles of 95 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 266 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Cuba 1 <1%
Unknown 265 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 3%
Unspecified 6 2%
Student > Ph. D. Student 2 <1%
Student > Master 1 <1%
Lecturer 1 <1%
Other 2 <1%
Unknown 247 93%
Readers by discipline Count As %
Unspecified 7 3%
Engineering 6 2%
Biochemistry, Genetics and Molecular Biology 2 <1%
Chemistry 2 <1%
Computer Science 2 <1%
Other 0 0%
Unknown 247 93%

Attention Score in Context

This research output has an Altmetric Attention Score of 124. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2018.
All research outputs
#125,413
of 13,632,354 outputs
Outputs from Annual Review of Medicine
#4
of 684 outputs
Outputs of similar age
#6,209
of 377,115 outputs
Outputs of similar age from Annual Review of Medicine
#1
of 1 outputs
Altmetric has tracked 13,632,354 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 684 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,115 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

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