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ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins

Overview of attention for article published in BMC Genomics, November 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#36 of 8,700)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

blogs
1 blog
twitter
112 tweeters

Citations

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28 Dimensions

Readers on

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64 Mendeley
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Title
ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins
Published in
BMC Genomics, November 2016
DOI 10.1186/s12864-016-3290-1
Pubmed ID
Authors

Emily R. Davenport, Julia K. Goodrich, Jordana T. Bell, Tim D. Spector, Ruth E. Ley, Andrew G. Clark

Abstract

Host genetics is one of several factors known to shape human gut microbiome composition, however, the physiological processes underlying the heritability are largely unknown. Inter-individual differences in host factors secreted into the gut lumen may lead to variation in microbiome composition. One such factor is the ABO antigen. This molecule is not only expressed on the surface of red blood cells, but is also secreted from mucosal surfaces in individuals containing an intact FUT2 gene (secretors). Previous studies report differences in microbiome composition across ABO and secretor genotypes. However, due to methodological limitations, the specific bacterial taxa involved remain unknown. Here, we sought to determine the relationship of the microbiota to ABO blood group and secretor status in a large panel of 1503 individuals from a cohort of twins from the United Kingdom. Contrary to previous reports, robust associations between either ABO or secretor phenotypes and gut microbiome composition were not detected. Overall community structure, diversity, and the relative abundances of individual taxa were not significantly associated with ABO or secretor status. Additionally, joint-modeling approaches were unsuccessful in identifying combinations of taxa that were predictive of ABO or secretor status. Despite previous reports, the taxonomic composition of the microbiota does not appear to be strongly associated with ABO or secretor status in 1503 individuals from the United Kingdom. These results highlight the importance of replicating microbiome-associated traits in large, well-powered cohorts to ensure results are robust.

Twitter Demographics

The data shown below were collected from the profiles of 112 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
France 1 2%
Unknown 61 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 33%
Student > Ph. D. Student 12 19%
Student > Bachelor 9 14%
Student > Master 6 9%
Student > Postgraduate 4 6%
Other 9 14%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 23%
Biochemistry, Genetics and Molecular Biology 12 19%
Immunology and Microbiology 7 11%
Medicine and Dentistry 6 9%
Nursing and Health Professions 5 8%
Other 11 17%
Unknown 8 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2018.
All research outputs
#334,794
of 15,362,096 outputs
Outputs from BMC Genomics
#36
of 8,700 outputs
Outputs of similar age
#13,207
of 387,275 outputs
Outputs of similar age from BMC Genomics
#8
of 872 outputs
Altmetric has tracked 15,362,096 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,700 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,275 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 872 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.