Title |
Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants
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Published in |
Microbiome, April 2013
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DOI | 10.1186/2049-2618-1-13 |
Pubmed ID | |
Authors |
Ardythe L Morrow, Anne J Lagomarcino, Kurt R Schibler, Diana H Taft, Zhuoteng Yu, Bo Wang, Mekibib Altaye, Michael Wagner, Dirk Gevers, Doyle V Ward, Michael A Kennedy, Curtis Huttenhower, David S Newburg |
Abstract |
Necrotizing enterocolitis (NEC) is a devastating intestinal disease that afflicts 10% of extremely preterm infants. The contribution of early intestinal colonization to NEC onset is not understood, and predictive biomarkers to guide prevention are lacking. We analyzed banked stool and urine samples collected prior to disease onset from infants <29 weeks gestational age, including 11 infants who developed NEC and 21 matched controls who survived free of NEC. Stool bacterial communities were profiled by 16S rRNA gene sequencing. Urinary metabolomic profiles were assessed by NMR. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 44% |
United Kingdom | 2 | 22% |
Mexico | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 89% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 5 | 2% |
United Kingdom | 2 | <1% |
Italy | 1 | <1% |
Saudi Arabia | 1 | <1% |
Unknown | 247 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 49 | 19% |
Student > Ph. D. Student | 47 | 18% |
Student > Bachelor | 23 | 9% |
Student > Master | 18 | 7% |
Student > Doctoral Student | 16 | 6% |
Other | 49 | 19% |
Unknown | 54 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 61 | 24% |
Medicine and Dentistry | 55 | 21% |
Biochemistry, Genetics and Molecular Biology | 24 | 9% |
Immunology and Microbiology | 15 | 6% |
Chemistry | 6 | 2% |
Other | 24 | 9% |
Unknown | 71 | 28% |