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Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines

Overview of attention for article published in Chinese Medicine, January 2010
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Citations

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48 Dimensions

Readers on

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82 Mendeley
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Title
Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines
Published in
Chinese Medicine, January 2010
DOI 10.1186/1749-8546-5-26
Pubmed ID
Authors

Stella Chai, Kenneth KW To, Ge Lin

Abstract

Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 3 4%
Chile 1 1%
Indonesia 1 1%
South Africa 1 1%
Unknown 76 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 21%
Student > Ph. D. Student 14 17%
Student > Bachelor 12 15%
Researcher 9 11%
Student > Doctoral Student 9 11%
Other 12 15%
Unknown 9 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 26%
Biochemistry, Genetics and Molecular Biology 15 18%
Pharmacology, Toxicology and Pharmaceutical Science 8 10%
Chemistry 8 10%
Medicine and Dentistry 8 10%
Other 11 13%
Unknown 11 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2012.
All research outputs
#2,900,900
of 3,635,050 outputs
Outputs from Chinese Medicine
#122
of 157 outputs
Outputs of similar age
#65,793
of 85,045 outputs
Outputs of similar age from Chinese Medicine
#4
of 4 outputs
Altmetric has tracked 3,635,050 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 157 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,045 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.