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Mendeley readers
Attention Score in Context
| Title |
Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines
|
|---|---|
| Published in |
Chinese Medicine, July 2010
|
| DOI | 10.1186/1749-8546-5-26 |
| Pubmed ID | |
| Authors |
Stella Chai, Kenneth KW To, Ge Lin |
| Abstract |
Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 3 | 3% |
| Indonesia | 1 | <1% |
| Chile | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 97 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 19% |
| Student > Ph. D. Student | 16 | 16% |
| Student > Bachelor | 16 | 16% |
| Student > Doctoral Student | 10 | 10% |
| Researcher | 8 | 8% |
| Other | 14 | 14% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 21% |
| Biochemistry, Genetics and Molecular Biology | 20 | 19% |
| Medicine and Dentistry | 11 | 11% |
| Chemistry | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
| Other | 11 | 11% |
| Unknown | 22 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2012.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Chinese Medicine
#517
of 660 outputs
Outputs of similar age
#98,990
of 103,926 outputs
Outputs of similar age from Chinese Medicine
#6
of 6 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 660 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,926 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.