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The regulation of cellular metabolism by tumor suppressor p53

Overview of attention for article published in Cell & Bioscience, April 2013
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Citations

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103 Mendeley
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Title
The regulation of cellular metabolism by tumor suppressor p53
Published in
Cell & Bioscience, April 2013
DOI 10.1186/2045-3701-3-9
Pubmed ID
Authors

Yingjian Liang, Juan Liu, Zhaohui Feng

Abstract

As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function in tumor suppression through its transcriptional regulation of its target genes to initiate various cellular responses. Cell cycle arrest, apoptosis and senescence are most well-understood functions of p53, and are traditionally accepted as the major mechanisms for p53 in tumor suppression. Recent studies have revealed a novel function of p53 in regulation of cellular metabolism. p53 regulates mitochondrial oxidative phosphorylation, glycolysis, glutamine metabolism, lipid metabolism, and antioxidant defense. Through the regulation of these metabolic processes, p53 maintains the homeostasis of cellular metabolism and redox balance in cells, which contributes significantly to the role of p53 as a tumor suppressor. Further understanding of the role and molecular mechanism of p53 in cellular metabolism could lead to the identification of novel targets and development of novel strategies for tumor therapy.

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Russia 1 <1%
Unknown 101 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 30%
Researcher 18 17%
Student > Bachelor 13 13%
Student > Master 11 11%
Professor > Associate Professor 7 7%
Other 17 17%
Unknown 6 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 46%
Biochemistry, Genetics and Molecular Biology 25 24%
Medicine and Dentistry 9 9%
Engineering 3 3%
Immunology and Microbiology 3 3%
Other 8 8%
Unknown 8 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2013.
All research outputs
#2,906,003
of 3,624,912 outputs
Outputs from Cell & Bioscience
#47
of 59 outputs
Outputs of similar age
#65,661
of 84,475 outputs
Outputs of similar age from Cell & Bioscience
#4
of 5 outputs
Altmetric has tracked 3,624,912 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 59 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,475 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.