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The regulation of cellular metabolism by tumor suppressor p53

Overview of attention for article published in Cell & Bioscience, February 2013
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147 Mendeley
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Title
The regulation of cellular metabolism by tumor suppressor p53
Published in
Cell & Bioscience, February 2013
DOI 10.1186/2045-3701-3-9
Pubmed ID
Authors

Yingjian Liang, Juan Liu, Zhaohui Feng

Abstract

As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy. Tumor suppressor p53 plays a central role in tumor prevention. As a transcription factor, p53 mainly exerts its function in tumor suppression through its transcriptional regulation of its target genes to initiate various cellular responses. Cell cycle arrest, apoptosis and senescence are most well-understood functions of p53, and are traditionally accepted as the major mechanisms for p53 in tumor suppression. Recent studies have revealed a novel function of p53 in regulation of cellular metabolism. p53 regulates mitochondrial oxidative phosphorylation, glycolysis, glutamine metabolism, lipid metabolism, and antioxidant defense. Through the regulation of these metabolic processes, p53 maintains the homeostasis of cellular metabolism and redox balance in cells, which contributes significantly to the role of p53 as a tumor suppressor. Further understanding of the role and molecular mechanism of p53 in cellular metabolism could lead to the identification of novel targets and development of novel strategies for tumor therapy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 146 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 27%
Researcher 23 16%
Student > Master 18 12%
Student > Bachelor 15 10%
Student > Doctoral Student 7 5%
Other 20 14%
Unknown 24 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 32%
Biochemistry, Genetics and Molecular Biology 45 31%
Medicine and Dentistry 10 7%
Engineering 5 3%
Immunology and Microbiology 4 3%
Other 10 7%
Unknown 26 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2013.
All research outputs
#20,190,878
of 22,707,247 outputs
Outputs from Cell & Bioscience
#791
of 915 outputs
Outputs of similar age
#249,699
of 282,983 outputs
Outputs of similar age from Cell & Bioscience
#9
of 10 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 915 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,983 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.