| Chapter title |
EBV-Directed T Cell Therapeutics for EBV-Associated Lymphomas.
|
|---|---|
| Chapter number | 19 |
| Book title |
Epstein Barr Virus
|
| Published in |
Methods in molecular biology, January 2017
|
| DOI | 10.1007/978-1-4939-6655-4_19 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6653-0, 978-1-4939-6655-4
|
| Authors |
Lauren P. McLaughlin, Stephen Gottschalk, Cliona M. Rooney, Catherine M. Bollard, McLaughlin, Lauren P., Gottschalk, Stephen, Rooney, Cliona M., Bollard, Catherine M. |
| Editors |
Janos Minarovits, Hans Helmut Niller |
| Abstract |
Epstein Barr virus (EBV) is a human gamma herpes virus that establishes latency in B cells after primary infection. EBV generally only causes a mild, self-limiting viral illness but is also associated with several malignancies including posttransplantation lymphoproliferative disorder in the immunosuppressed host as well as Hodgkin and non-Hodgkin lymphoma in the immune competent host. The expression of EBV antigens by lymphoma has important applications as targets for adoptive T cell therapy. However, as many lymphomas only express subdominant EBV antigens that are less immunogenic, novel strategies are needed to manufacture EBV-specific T cell products specific for Latent Membrane Protein 1 (LMP1) and LMP2, which are expressed in lymphomas with type II and III latency. While several techniques for manufacturing EBV-CTLs are described in the literature, this chapter focuses on one method for generating Good Manufacturing Practice (GMP)-compliant EBV-specific T cell products that are enriched with LMP1 and LMP2. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 20% |
| Researcher | 2 | 13% |
| Student > Doctoral Student | 1 | 7% |
| Other | 1 | 7% |
| Student > Ph. D. Student | 1 | 7% |
| Other | 3 | 20% |
| Unknown | 4 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 33% |
| Biochemistry, Genetics and Molecular Biology | 3 | 20% |
| Immunology and Microbiology | 2 | 13% |
| Agricultural and Biological Sciences | 1 | 7% |
| Unknown | 4 | 27% |