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Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics

Overview of attention for article published in Bioorganic & Medicinal Chemistry Letters, November 2009
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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1 tweeter
patent
1 patent

Citations

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12 Dimensions

Readers on

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17 Mendeley
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Title
Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics
Published in
Bioorganic & Medicinal Chemistry Letters, November 2009
DOI 10.1016/j.bmcl.2009.08.090
Pubmed ID
Authors

Lori W. Lee, Christopher E.C. Taylor, Jean-Paul Desaulniers, Manchao Zhang, Jonas W. Højfeldt, Quintin Pan, Anna K. Mapp

Abstract

Small molecules that mimic the transcriptional activation domain of eukaryotic transcriptional activators have the potential to serve as effective inhibitors of transcriptional processes. Here we show that one class of transcriptional activation domain mimics, amphipathic isoxazolidines, can be converted into inhibitors of gene expression mediated by the transcriptional activator ESX through small structural modifications. Addition of the small molecules leads to decreased expression of the cell surface growth receptor ErbB2(Her2) in ErbB2-positive cancer cells and, correspondingly, decreased proliferation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Researcher 5 29%
Student > Master 2 12%
Lecturer 1 6%
Student > Bachelor 1 6%
Other 2 12%
Unknown 1 6%
Readers by discipline Count As %
Chemistry 8 47%
Agricultural and Biological Sciences 5 29%
Immunology and Microbiology 1 6%
Neuroscience 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 0 0%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2013.
All research outputs
#3,289,818
of 12,272,424 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#3,563
of 10,352 outputs
Outputs of similar age
#36,806
of 140,328 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#24
of 86 outputs
Altmetric has tracked 12,272,424 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 10,352 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.