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Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Overview of attention for article published in Nature Communications, November 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

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11 news outlets
blogs
2 blogs
twitter
17 X users
facebook
2 Facebook pages

Citations

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76 Dimensions

Readers on

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98 Mendeley
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Title
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
Published in
Nature Communications, November 2016
DOI 10.1038/ncomms13649
Pubmed ID
Authors

Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich, David Vilchez

Abstract

Human embryonic stem cells can replicate indefinitely while maintaining their undifferentiated state and, therefore, are immortal in culture. This capacity may demand avoidance of any imbalance in protein homeostasis (proteostasis) that would otherwise compromise stem cell identity. Here we show that human pluripotent stem cells exhibit enhanced assembly of the TRiC/CCT complex, a chaperonin that facilitates the folding of 10% of the proteome. We find that ectopic expression of a single subunit (CCT8) is sufficient to increase TRiC/CCT assembly. Moreover, increased TRiC/CCT complex is required to avoid aggregation of mutant Huntingtin protein. We further show that increased expression of CCT8 in somatic tissues extends Caenorhabditis elegans lifespan in a TRiC/CCT-dependent manner. Ectopic expression of CCT8 also ameliorates the age-associated demise of proteostasis and corrects proteostatic deficiencies in worm models of Huntington's disease. Our results suggest proteostasis is a common principle that links organismal longevity with hESC immortality.

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 98 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 20%
Student > Ph. D. Student 17 17%
Student > Bachelor 11 11%
Student > Master 8 8%
Other 8 8%
Other 21 21%
Unknown 13 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 37 38%
Agricultural and Biological Sciences 28 29%
Neuroscience 6 6%
Unspecified 2 2%
Immunology and Microbiology 2 2%
Other 9 9%
Unknown 14 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 97. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2018.
All research outputs
#378,933
of 23,342,664 outputs
Outputs from Nature Communications
#6,364
of 48,305 outputs
Outputs of similar age
#8,628
of 419,339 outputs
Outputs of similar age from Nature Communications
#140
of 810 outputs
Altmetric has tracked 23,342,664 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 48,305 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,339 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 810 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.