Stem Cell-Derived Models in Toxicology

Chapter 1 Stem Cell-Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space”

Chapter 2 Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk

Chapter 3 Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology

Chapter 4 Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes

Chapter 5 The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential

Chapter 6 Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions

Chapter 7 HTS-Compatible Voltage- and Ca 2+ -Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems

Chapter 8 Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes

Chapter 9 Decoding Ca 2+ Signals as a Non-electrophysiological Method for Assessing Drug Toxicity in Stem Cell-Derived Cardiomyocytes

Chapter 10 Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes

Chapter 11 Edge-Detection for Contractility Measurements with Cardiac Spheroids

Chapter 12 Contractile Force Readout of hESC-Cardiomyocytes

Chapter 13 In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models

Chapter 14 Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Chapter 15 Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA)

Chapter 16 Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies