Title |
SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway
|
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Published in |
Cardiovascular Research, August 2012
|
DOI | 10.1093/cvr/cvs261 |
Pubmed ID | |
Authors |
Antonio Cittadini, Maria Gaia Monti, Guido Iaccarino, Maria Carmina Castiello, Alfonso Baldi, Eduardo Bossone, Salvatore Longobardi, Alberto Maria Marra, Valentina Petrillo, Lavinia Saldamarco, Matthew John During, Luigi Saccà, Gianluigi Condorelli |
Abstract |
The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertrophy to heart failure. To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique in a chronic pressure-overload cardiac rat model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 23% |
Researcher | 7 | 18% |
Professor > Associate Professor | 6 | 15% |
Professor | 2 | 5% |
Student > Master | 2 | 5% |
Other | 4 | 10% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 36% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Immunology and Microbiology | 2 | 5% |
Psychology | 2 | 5% |
Other | 3 | 8% |
Unknown | 9 | 23% |