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Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia

Overview of attention for article published in Clinical Epigenetics, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

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7 tweeters

Citations

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59 Dimensions

Readers on

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56 Mendeley
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Title
Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia
Published in
Clinical Epigenetics, January 2013
DOI 10.1186/1868-7083-5-6
Pubmed ID
Authors

Deepali P Sundrani, Umakar S Reddy, Asmita A Joshi, Savita S Mehendale, Preeti M Chavan-Gautam, Anandwardhan A Hardikar, Giriraj R Chandak, Sadhana R Joshi

Abstract

Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we have observed changes in placental global DNA methylation levels in preeclampsia, this study was undertaken to examine gene promoter CpG methylation and expression of several angiogenic genes.We recruited 139 women comprising, 46 normotensive women with term delivery (≥37 weeks), 45 women with preeclampsia delivering preterm (<37 weeks) and 48 women with preeclampsia delivering at term. Expression levels and promoter CpG methylation of VEGF, FLT-1 and KDR genes in placentae from respective groups were determined by Taqman-based quantitative real time PCR and by the Sequenom® EpiTYPER™ technology respectively.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
India 1 2%
Netherlands 1 2%
Unknown 53 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 30%
Researcher 7 13%
Student > Bachelor 7 13%
Student > Master 5 9%
Professor > Associate Professor 5 9%
Other 12 21%
Unknown 3 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 34%
Agricultural and Biological Sciences 18 32%
Medicine and Dentistry 10 18%
Computer Science 1 2%
Immunology and Microbiology 1 2%
Other 3 5%
Unknown 4 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2013.
All research outputs
#946,220
of 4,507,144 outputs
Outputs from Clinical Epigenetics
#79
of 207 outputs
Outputs of similar age
#22,241
of 88,546 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 1 outputs
Altmetric has tracked 4,507,144 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 207 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 88,546 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them