↓ Skip to main content

The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol

Overview of attention for article published in Systematic Reviews, November 2016
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
91 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol
Published in
Systematic Reviews, November 2016
DOI 10.1186/s13643-016-0386-2
Pubmed ID
Authors

Daniel S. Quintana, Tim Outhred, Lars T. Westlye, Gin S. Malhi, Ole A. Andreassen

Abstract

Converging evidence demonstrates the important role of the neuropeptide hormone oxytocin (OT) in human behaviour and cognition. Intranasal OT administration has been shown to improve several aspects of social communication, such as the theory of mind performance and gaze to the eye region, and reduce anxiety and related negative cognitive appraisals. While this early research has demonstrated the potential for intranasal OT to treat psychiatric illnesses characterized by social impairments, the neurobiological mechanisms are not well known. Researchers have used functional magnetic resonance imaging (fMRI) to examine the neural correlates of OT response; however, results have been variable and moderating factors are poorly understood. The aim of this meta-analysis is to synthesize data examining the impact of intranasal OT administration on neural activity. Studies that report fMRI data after intranasal OT administration will be identified. PubMed, Embase, PsycINFO, and Google Scholar databases will be searched as well as the citation lists of retrieved articles. Eligible articles written in English from 2005 onwards will be included in the meta-analysis, and corresponding authors of these papers will be invited to contribute t-maps. Data will be collected from eligible studies for synthesis using Seed-based d Mapping (SDM) or Multi-Level Kernel Density Analysis (MKDA), depending on the number of usable t-maps received. Additionally, publication bias and risk of bias will be assessed. This systematic review and meta-analysis will be the first pre-registered synthesis of data to identify the neural correlates of OT nasal spray response. The identification of brain regions underlying OT's observed effects will help guide future research and better identify treatment targets. PROSPERO CRD42016038781.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 90 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 25%
Researcher 15 16%
Student > Master 11 12%
Student > Doctoral Student 7 8%
Student > Bachelor 6 7%
Other 12 13%
Unknown 17 19%
Readers by discipline Count As %
Psychology 29 32%
Neuroscience 12 13%
Medicine and Dentistry 8 9%
Agricultural and Biological Sciences 4 4%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 12 13%
Unknown 23 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2017.
All research outputs
#17,828,338
of 22,903,988 outputs
Outputs from Systematic Reviews
#1,706
of 2,002 outputs
Outputs of similar age
#287,773
of 416,538 outputs
Outputs of similar age from Systematic Reviews
#37
of 40 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,002 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,538 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.