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Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

Overview of attention for article published in Scientific Reports, November 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

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11 tweeters
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1 research highlight platform

Citations

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40 Dimensions

Readers on

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109 Mendeley
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Title
Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo
Published in
Scientific Reports, November 2016
DOI 10.1038/srep37944
Pubmed ID
Authors

Eleonora Ciarlo, Tytti Heinonen, Jacobus Herderschee, Craig Fenwick, Matteo Mombelli, Didier Le Roy, Thierry Roger

Abstract

Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibitors of histone deacetylases which are known to interfere with host defenses. Here we show that propionate, one of the main SCFAs, dampens the response of innate immune cells to microbial stimulation, inhibiting cytokine and NO production by mouse or human monocytes/macrophages, splenocytes, whole blood and, less efficiently, dendritic cells. In proof of concept studies, propionate neither improved nor worsened morbidity and mortality parameters in models of endotoxemia and infections induced by gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae), gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae) and Candida albicans. Moreover, propionate did not impair the efficacy of passive immunization and natural immunization. Therefore, propionate has no significant impact on host susceptibility to infections and the establishment of protective anti-bacterial responses. These data support the safety of propionate-based therapies, either via direct supplementation or via the diet/microbiota, to treat non-infectious inflammation-related disorders, without increasing the risk of infection.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 108 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 19%
Student > Bachelor 19 17%
Student > Ph. D. Student 19 17%
Student > Master 17 16%
Student > Doctoral Student 7 6%
Other 16 15%
Unknown 10 9%
Readers by discipline Count As %
Immunology and Microbiology 31 28%
Agricultural and Biological Sciences 27 25%
Biochemistry, Genetics and Molecular Biology 20 18%
Medicine and Dentistry 7 6%
Nursing and Health Professions 3 3%
Other 7 6%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2018.
All research outputs
#2,799,478
of 16,407,948 outputs
Outputs from Scientific Reports
#21,831
of 87,703 outputs
Outputs of similar age
#80,464
of 393,152 outputs
Outputs of similar age from Scientific Reports
#1,240
of 4,749 outputs
Altmetric has tracked 16,407,948 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 87,703 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,152 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 4,749 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.