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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interferon-induced guanylate-binding proteins in inflammasome activation and host defense
|
|---|---|
| Published in |
Nature Immunology, April 2016
|
| DOI | 10.1038/ni.3440 |
| Pubmed ID | |
| Authors |
Bae-Hoon Kim, Jonathan D Chee, Clinton J Bradfield, Eui-Soon Park, Pradeep Kumar, John D MacMicking |
| Abstract |
Traditional views of the inflammasome highlight the assembly of pre-existing core components shortly after infection or tissue damage. Emerging work, however, suggests that the inflammasome machinery is also subject to 'tunable' or inducible signals that might accelerate its autocatalytic properties and dictate where inflammasome assembly takes place in the cell. Many of these signals operate downstream of interferon receptors to elicit inflammasome regulators, including a new family of interferon-induced GTPases called 'guanylate-binding proteins' (GBPs). Here we investigate the critical roles of interferon-induced GBPs in directing inflammasome subtype-specific responses and their consequences for cell-autonomous immunity to a wide variety of microbial pathogens. We discuss emerging mechanisms of action and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflammatory diseases. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Spain | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 40% |
| Members of the public | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 2 | 1% |
| Brazil | 1 | <1% |
| Unknown | 172 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 22% |
| Researcher | 22 | 13% |
| Student > Master | 21 | 12% |
| Student > Bachelor | 14 | 8% |
| Student > Doctoral Student | 11 | 6% |
| Other | 31 | 18% |
| Unknown | 37 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 25% |
| Immunology and Microbiology | 40 | 23% |
| Biochemistry, Genetics and Molecular Biology | 25 | 14% |
| Medicine and Dentistry | 11 | 6% |
| Chemistry | 3 | 2% |
| Other | 12 | 7% |
| Unknown | 40 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2023.
All research outputs
#6,406,971
of 25,837,817 outputs
Outputs from Nature Immunology
#2,470
of 4,229 outputs
Outputs of similar age
#83,305
of 315,988 outputs
Outputs of similar age from Nature Immunology
#47
of 66 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,229 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,988 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.