Title |
A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products
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Published in |
Malaria Journal, April 2013
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DOI | 10.1186/1475-2875-12-145 |
Pubmed ID | |
Authors |
Sultan Suleman, Kirsten Vandercruyssen, Evelien Wynendaele, Matthias D’Hondt, Nathalie Bracke, Luc Duchateau, Christian Burvenich, Kathelijne Peremans, Bart De Spiegeleer |
Abstract |
Artemisinin-based fixed dose combination (FDC) products are recommended by World Health Organization (WHO) as a first-line treatment. However, the current artemisinin FDC products, such as β-artemether and lumefantrine, are inherently unstable and require controlled distribution and storage conditions, which are not always available in resource-limited settings. Moreover, quality control is hampered by lack of suitable analytical methods. Thus, there is a need for a rapid and simple, but stability-indicating method for the simultaneous assay of β-artemether and lumefantrine FDC products. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 2% |
Ghana | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 57 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 23% |
Student > Master | 11 | 18% |
Researcher | 7 | 12% |
Student > Doctoral Student | 6 | 10% |
Lecturer | 2 | 3% |
Other | 7 | 12% |
Unknown | 13 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 22% |
Chemistry | 10 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 15% |
Agricultural and Biological Sciences | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 7 | 12% |
Unknown | 14 | 23% |