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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche
|
|---|---|
| Published in |
Skeletal Muscle, December 2016
|
| DOI | 10.1186/s13395-016-0111-9 |
| Pubmed ID | |
| Authors |
Ivana Dinulovic, Regula Furrer, Markus Beer, Arnaud Ferry, Bettina Cardel, Christoph Handschin |
| Abstract |
The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key regulator of oxidative metabolism and endurance training adaptation. However, a link between PGC-1α and SC behavior remains unexplored. We have now studied SC function in a PGC-1α fiber-specific gain-of-function animal model. In surprising contrast to bona fide exercise, muscle-specific PGC-1α transgenic mice have lower SC numbers. Nevertheless, SCs from these mice have a higher propensity for activation and proliferation. Intriguingly, muscle PGC-1α triggers a remodeling of the SC niche by altering the extracellular matrix composition, including the levels of fibronectin, which affects the proliferative output of SCs. Taken together, PGC-1α indirectly affects SC plasticity in skeletal muscle and thereby might contribute to improved SC activation in exercise. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 31% |
| Canada | 2 | 8% |
| United Kingdom | 2 | 8% |
| Norway | 1 | 4% |
| Ireland | 1 | 4% |
| Brazil | 1 | 4% |
| France | 1 | 4% |
| Australia | 1 | 4% |
| Taiwan | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 7 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 50% |
| Scientists | 9 | 35% |
| Practitioners (doctors, other healthcare professionals) | 3 | 12% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 62 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 12 | 19% |
| Researcher | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 9 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 39% |
| Agricultural and Biological Sciences | 12 | 19% |
| Medicine and Dentistry | 4 | 6% |
| Nursing and Health Professions | 2 | 3% |
| Sports and Recreations | 2 | 3% |
| Other | 9 | 14% |
| Unknown | 10 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2023.
All research outputs
#1,305,524
of 25,085,000 outputs
Outputs from Skeletal Muscle
#16
of 385 outputs
Outputs of similar age
#26,224
of 427,768 outputs
Outputs of similar age from Skeletal Muscle
#3
of 11 outputs
Altmetric has tracked 25,085,000 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 385 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 427,768 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.