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Understanding how we age: insights into inflammaging

Overview of attention for article published in Longevity & Healthspan, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

blogs
2 blogs
twitter
12 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
191 Dimensions

Readers on

mendeley
297 Mendeley
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Title
Understanding how we age: insights into inflammaging
Published in
Longevity & Healthspan, May 2013
DOI 10.1186/2046-2395-2-8
Pubmed ID
Authors

Daniel Baylis, David B Bartlett, Harnish P Patel, Helen C Roberts

Abstract

Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.Inflammaging is believed to be a consequence of a remodelling of the innate and acquired immune system, resulting in chronic inflammatory cytokine production.Complex interrelated genetic, environmental and age-related factors determine an individual's vulnerability or resilience to inflammaging. These factors include polymorphisms to the promoter regions of cytokines, cytokine receptors and antagonists, age-related decreases in autophagy and increased adiposity. Anti-inflammaging describes the upregulation of the hypothalamic-pituitary axis in response to inflammaging, leading to higher levels of cortisol, which in turn may be detrimental, contributing to less successful ageing and frailty. This may be countered by the adrenal steroid dehydroepiandrosterone, which itself declines with age, leaving certain individuals more vulnerable. Inflammaging and anti-inflammaging have both been linked with a number of age-related outcomes, including chronic morbidity, functional decline and mortality. This important area of research offers unique insights into the ageing process and the potential for screening and targeted interventions.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 297 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 2 <1%
Brazil 2 <1%
United States 2 <1%
Canada 1 <1%
United Kingdom 1 <1%
Unknown 289 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 59 20%
Student > Bachelor 55 19%
Student > Ph. D. Student 42 14%
Researcher 40 13%
Student > Doctoral Student 21 7%
Other 52 18%
Unknown 28 9%
Readers by discipline Count As %
Medicine and Dentistry 73 25%
Biochemistry, Genetics and Molecular Biology 54 18%
Agricultural and Biological Sciences 53 18%
Immunology and Microbiology 18 6%
Neuroscience 10 3%
Other 52 18%
Unknown 37 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2018.
All research outputs
#890,714
of 15,922,193 outputs
Outputs from Longevity & Healthspan
#5
of 24 outputs
Outputs of similar age
#9,306
of 156,344 outputs
Outputs of similar age from Longevity & Healthspan
#1
of 1 outputs
Altmetric has tracked 15,922,193 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 24 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one scored the same or higher as 19 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them