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Common variants in WFS1 confer risk of type 2 diabetes

Overview of attention for article published in Nature Genetics, July 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
2 blogs
patent
1 patent

Citations

dimensions_citation
275 Dimensions

Readers on

mendeley
115 Mendeley
citeulike
1 CiteULike
connotea
3 Connotea
Title
Common variants in WFS1 confer risk of type 2 diabetes
Published in
Nature Genetics, July 2007
DOI 10.1038/ng2067
Pubmed ID
Authors

Manjinder S Sandhu, Michael N Weedon, Katherine A Fawcett, Jon Wasson, Sally L Debenham, Allan Daly, Hana Lango, Timothy M Frayling, Rosalind J Neumann, Richard Sherva, Ilana Blech, Paul D Pharoah, Colin N A Palmer, Charlotte Kimber, Roger Tavendale, Andrew D Morris, Mark I McCarthy, Mark Walker, Graham Hitman, Benjamin Glaser, M Alan Permutt, Andrew T Hattersley, Nicholas J Wareham, Inês Barroso

Abstract

We studied genes involved in pancreatic beta cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Italy 1 <1%
Korea, Republic of 1 <1%
France 1 <1%
Switzerland 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 106 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 34 30%
Student > Ph. D. Student 25 22%
Other 11 10%
Student > Master 11 10%
Professor > Associate Professor 10 9%
Other 18 16%
Unknown 6 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 39%
Biochemistry, Genetics and Molecular Biology 25 22%
Medicine and Dentistry 22 19%
Neuroscience 2 2%
Mathematics 2 2%
Other 9 8%
Unknown 10 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2019.
All research outputs
#1,057,457
of 14,909,741 outputs
Outputs from Nature Genetics
#1,859
of 6,375 outputs
Outputs of similar age
#11,990
of 154,233 outputs
Outputs of similar age from Nature Genetics
#42
of 68 outputs
Altmetric has tracked 14,909,741 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,375 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,233 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.