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Brachytherapy-emulating robotic radiosurgery in patients with cervical carcinoma

Overview of attention for article published in Radiation Oncology, May 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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1 tweeter
facebook
5 Facebook pages

Citations

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27 Dimensions

Readers on

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35 Mendeley
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Title
Brachytherapy-emulating robotic radiosurgery in patients with cervical carcinoma
Published in
Radiation Oncology, May 2013
DOI 10.1186/1748-717x-8-109
Pubmed ID
Authors

Simone Marnitz, Christhardt Köhler, Volker Budach, Oliver Neumann, Anne Kluge, Waldemar Wlodarczyk, Ulrich Jahn, Bernhard Gebauer, Markus Kufeld

Abstract

PurposeTo evaluate the technique, dosimetry, dose-volume-histograms (DVHs) and acute toxicity for CyberKnife® boost irradiation instead of intra-cervical brachytherapy in patients with cervical cancer.Methods and materialsEleven who were not suitable for brachytherapy with FIGO stage IIB-IIIB cervical cancer underwent primary chemoradiation. After fiducial implantation, T2 contrast-enhanced planning MRI and CT scans at 2-mm slice thickness were collected in the treatment position. The clinical target volume was defined as cervix + macroscopic residual tumour on MRI. Five fractions of 6 Gy each were prescribed to the target volume with a covering isodose between 60-70%. DVH parameters were evaluated for the target and organs at risk. Acute toxicity was documented once a week. RESULTS: DmeanPTV ranged from 33.6-40 Gy, median 36.7 Gy with a coverage of the PTV calculated to 100% of the prescribed dose ranging from 93.0-99.3% (median 97.7%). For the PTV the median CN was 0.78 (range, 0.66 to 0.87) and the median CI was 1.28 (range 1.15 to 1.52). Gastrointestinal (GI) and genitourinary (GU) toxicity was mild. There was no grade 3 or higher GI and GU toxicity. After 6 months of follow up, there were no local recurrences. For the complete treatment, a median EQD2 to 1 cc and 2 cc of the bladder wall was 98.8 Gy and 87.1 Gy, respectively. Median EQD2 to 1 cc and 2 cc of the rectal wall was 72.3 Gy and 64 Gy, respectively, correlating with a risk < 10% for Grade 2-4 late toxicity. CONCLUSIONS: CyberKnife robotic radiosurgery in patients with cervical cancer provides excellent target coverage with steep dose gradients toward normal tissues and safe DVH parameters for bladder, rectum and sigmoid. Acute toxicity was mild. Longer follow-up is needed to evaluate the oncological benefit.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Philippines 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 26%
Researcher 5 14%
Other 3 9%
Student > Bachelor 3 9%
Student > Ph. D. Student 3 9%
Other 8 23%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 16 46%
Nursing and Health Professions 4 11%
Physics and Astronomy 3 9%
Agricultural and Biological Sciences 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 11%
Unknown 6 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2013.
All research outputs
#1,928,363
of 4,507,280 outputs
Outputs from Radiation Oncology
#302
of 826 outputs
Outputs of similar age
#35,039
of 89,203 outputs
Outputs of similar age from Radiation Oncology
#12
of 28 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 826 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,203 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.