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A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis.

Overview of attention for article published in American Journal of Translational Research, September 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

blogs
1 blog

Citations

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14 Dimensions

Readers on

mendeley
11 Mendeley
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Title
A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis.
Published in
American Journal of Translational Research, September 2012
Pubmed ID
Authors

Wang L, Liu R, Li D, Lin S, Fang X, Backer G, Kain M, Rammoham K, Zheng P, Liu Y

Abstract

A large number of risk alleles have been identified for multiple sclerosis (MS). However, how genetic variations may affect pathogenesis remains largely unknown for most risk alleles. Through direct sequencing of CD24 promoter region, we identified a cluster of 7 new single nucleotide polymorphisms in the CD24 promoter. A hypermorphic haplotype consisting of 3 SNPs was identified through association studies consisting of 935 control and 764 MS patients (P=0.001, odds ratio 1.3). The variant is also associated with more rapid progression of MS (P=0.016, log rank test). In cells that are heterozygous for the risk allele, chromatin immunoprecipitation revealed that risk allele specifically bind to a transcription factor SP1, which is selectively required for the hypermorphic promoter activity of the variant. In MS patients, the CD24 transcript levels associate with the SP1-binding variant in a dose-dependent manner (P=7x10(-4)). Our data revealed a potential role for SP1-mediated transcriptional regulation in MS pathogenesis.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 36%
Student > Bachelor 2 18%
Researcher 2 18%
Other 1 9%
Student > Master 1 9%
Other 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 55%
Medicine and Dentistry 2 18%
Biochemistry, Genetics and Molecular Biology 1 9%
Immunology and Microbiology 1 9%
Unspecified 1 9%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2012.
All research outputs
#486,436
of 3,628,714 outputs
Outputs from American Journal of Translational Research
#6
of 66 outputs
Outputs of similar age
#14,134
of 85,185 outputs
Outputs of similar age from American Journal of Translational Research
#1
of 2 outputs
Altmetric has tracked 3,628,714 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 66 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,185 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them