Title |
Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice
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Published in |
Microbiology and Immunology, April 2023
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DOI | 10.1111/1348-0421.13066 |
Pubmed ID | |
Authors |
Koichiro Suzuki, Yukihiro Hiramatsu, Takashi Nishida, Yasuhiko Horiguchi |
Abstract |
Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B. pertussis, virulence-associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing after B. pertussis infection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough. This article is protected by copyright. All rights reserved. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |