You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Evolution of pharmacologic specificity in the pregnane X receptor
|
|---|---|
| Published in |
BMC Ecology and Evolution, April 2008
|
| DOI | 10.1186/1471-2148-8-103 |
| Pubmed ID | |
| Authors |
Sean Ekins, Erica J Reschly, Lee R Hagey, Matthew D Krasowski |
| Abstract |
The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study, we determined the pharmacophores for activation of human, mouse, rat, rabbit, chicken, and zebrafish PXRs, using a common set of sixteen ligands. In addition, we compared in detail the selectivity of human and zebrafish PXRs for steroidal compounds and xenobiotics. The ligand activation properties of the Western clawed frog (Xenopus tropicalis) PXR and that of a putative vitamin D receptor (VDR)/PXR cloned in this study from the chordate invertebrate sea squirt (Ciona intestinalis) were also investigated. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Germany | 2 | 3% |
| Colombia | 1 | 2% |
| India | 1 | 2% |
| Finland | 1 | 2% |
| Unknown | 52 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 27% |
| Researcher | 13 | 22% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 7 | 12% |
| Lecturer | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 5 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 42% |
| Chemistry | 7 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Environmental Science | 5 | 8% |
| Other | 5 | 8% |
| Unknown | 7 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2019.
All research outputs
#4,261,824
of 25,374,917 outputs
Outputs from BMC Ecology and Evolution
#1,092
of 3,714 outputs
Outputs of similar age
#14,899
of 95,951 outputs
Outputs of similar age from BMC Ecology and Evolution
#13
of 52 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.