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An ancient and variable mannose-binding lectin from the coral Acropora millepora binds both pathogens and symbionts

Overview of attention for article published in Developmental & Comparative Immunology, January 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
1 blog

Citations

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110 Dimensions

Readers on

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163 Mendeley
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Title
An ancient and variable mannose-binding lectin from the coral Acropora millepora binds both pathogens and symbionts
Published in
Developmental & Comparative Immunology, January 2008
DOI 10.1016/j.dci.2008.05.010
Pubmed ID
Authors

E. Charlotte E. Kvennefors, William Leggat, Ove Hoegh-Guldberg, Bernard M. Degnan, Andrew C. Barnes

Abstract

Corals form the framework of the world's coral reefs and are under threat from increases in disease and bleaching (symbiotic dysfunction), yet the mechanisms of pathogen and symbiont recognition remain largely unknown. Here we describe the isolation and characterisation of an ancient mannose-binding lectin in the coral Acropora millepora, which is likely to be involved in both processes. The lectin ('Millectin') was isolated by affinity chromatography and was shown to bind to bacterial pathogens as well as coral symbionts, dinoflagellates of the genus Symbiodinium. cDNA analysis of Millectin indicate extensive sequence variation in the binding region, reflecting its ability to recognise various mannose-like carbohydrate structures on non-self cells, including symbionts and pathogens. This is the first mannose-binding lectin to show extensive sequence variability as observed for pattern recognition proteins in other invertebrate immune systems and, given that invertebrates rely on non-adaptive immunity, is a potential keystone component of coral defence mechanisms.

Mendeley readers

The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Australia 2 1%
Taiwan 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Norway 1 <1%
Kenya 1 <1%
Belgium 1 <1%
Austria 1 <1%
Other 1 <1%
Unknown 150 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 51 31%
Researcher 36 22%
Student > Master 20 12%
Student > Bachelor 14 9%
Professor > Associate Professor 8 5%
Other 34 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 103 63%
Biochemistry, Genetics and Molecular Biology 19 12%
Environmental Science 18 11%
Unspecified 10 6%
Social Sciences 5 3%
Other 8 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2013.
All research outputs
#2,817,892
of 12,277,248 outputs
Outputs from Developmental & Comparative Immunology
#74
of 1,076 outputs
Outputs of similar age
#30,408
of 141,112 outputs
Outputs of similar age from Developmental & Comparative Immunology
#1
of 6 outputs
Altmetric has tracked 12,277,248 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,076 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them