↓ Skip to main content

Seizure burden and neurodevelopmental outcome in neonates with hypoxic–ischemic encephalopathy

Overview of attention for article published in Developmental Medicine & Child Neurology, September 2016
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
119 Dimensions

Readers on

mendeley
147 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Seizure burden and neurodevelopmental outcome in neonates with hypoxic–ischemic encephalopathy
Published in
Developmental Medicine & Child Neurology, September 2016
DOI 10.1111/dmcn.13215
Pubmed ID
Authors

Liudmila Kharoshankaya, Nathan J Stevenson, Vicki Livingstone, Deirdre M Murray, Brendan P Murphy, Caroline E Ahearne, Geraldine B Boylan

Abstract

To examine the relationship between electrographic seizures and long-term outcome in neonates with hypoxic-ischemic encephalopathy (HIE). Full-term neonates with HIE born in Cork University Maternity Hospital from 2003 to 2006 (pre-hypothermia era) and 2009 to 2012 (hypothermia era) were included in this observational study. All had early continuous electroencephalography monitoring. All electrographic seizures were annotated. The total seizure burden and hourly seizure burden were calculated. Outcome (normal/abnormal) was assessed at 24 to 48 months in surviving neonates using either the Bayley Scales of Infant and Toddler Development, Third Edition or the Griffiths Mental Development Scales; a diagnosis of cerebral palsy or epilepsy was also considered an abnormal outcome. Continuous electroencephalography was recorded for a median of 57.1 hours (interquartile range 33.5-80.5h) in 47 neonates (31 males, 16 females); 29 out of 47 (62%) had electrographic seizures and 25 out of 47 (53%) had an abnormal outcome. The presence of seizures per se was not associated with abnormal outcome (p=0.126); however, the odds of an abnormal outcome increased over ninefold (odds ratio [OR] 9.56; 95% confidence interval [95% CI] 2.43-37.67) if a neonate had a total seizure burden of more than 40 minutes (p=0.001), and eightfold (OR: 8.00; 95% CI: 2.06-31.07) if a neonate had a maximum hourly seizure burden of more than 13 minutes per hour (p=0.003). Controlling for electrographic HIE grade or treatment with hypothermia did not change the direction of the relationship between seizure burden and outcome. In HIE, a high electrographic seizure burden is significantly associated with abnormal outcome, independent of HIE severity or treatment with hypothermia.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 146 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 15%
Student > Postgraduate 19 13%
Student > Master 19 13%
Researcher 17 12%
Student > Bachelor 16 11%
Other 28 19%
Unknown 26 18%
Readers by discipline Count As %
Medicine and Dentistry 56 38%
Neuroscience 27 18%
Nursing and Health Professions 9 6%
Psychology 5 3%
Engineering 3 2%
Other 10 7%
Unknown 37 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2017.
All research outputs
#10,381,480
of 17,362,547 outputs
Outputs from Developmental Medicine & Child Neurology
#2,274
of 3,433 outputs
Outputs of similar age
#197,391
of 397,370 outputs
Outputs of similar age from Developmental Medicine & Child Neurology
#27
of 54 outputs
Altmetric has tracked 17,362,547 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,433 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,370 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.