Title |
Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis
|
---|---|
Published in |
BMC Infectious Diseases, May 2013
|
DOI | 10.1186/1471-2334-13-207 |
Pubmed ID | |
Authors |
Guanghui Zhao, Aihua Zhou, Gang Lv, Min Meng, Min Sun, Yang Bai, Yali Han, Lin Wang, Huaiyu Zhou, Hua Cong, Qunli Zhao, Xing-Quan Zhu, Shenyi He |
Abstract |
Toxoplasma gondii, an obligate intracellular apicomplexan parasite, infects a wide range of warm-blooded animals including humans. T. gondii expresses five members of the C1 family of cysteine proteases, including cathepsin B-like (TgCPB) and cathepsin L-like (TgCPL) proteins. TgCPB is involved in ROP protein maturation and parasite invasion, whereas TgCPL contributes to proteolytic maturation of proTgM2AP and proTgMIC3. TgCPL is also associated with the residual body in the parasitophorous vacuole after cell division has occurred. Both of these proteases are potential therapeutic targets in T. gondii. The aim of this study was to investigate TgCPB and TgCPL for their potential as DNA vaccines against T. gondii. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 2% |
Austria | 1 | 2% |
Unknown | 39 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 20% |
Student > Ph. D. Student | 6 | 15% |
Student > Master | 5 | 12% |
Student > Bachelor | 4 | 10% |
Student > Postgraduate | 4 | 10% |
Other | 5 | 12% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 22% |
Veterinary Science and Veterinary Medicine | 6 | 15% |
Medicine and Dentistry | 6 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Immunology and Microbiology | 3 | 7% |
Other | 4 | 10% |
Unknown | 10 | 24% |