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Minocycline Treatment Inhibits Microglial Activation and Alters Spinal Levels of Endocannabinoids in a Rat Model of Neuropathic Pain

Overview of attention for article published in Molecular Pain, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 464)
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
98 Mendeley
citeulike
2 CiteULike
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Title
Minocycline Treatment Inhibits Microglial Activation and Alters Spinal Levels of Endocannabinoids in a Rat Model of Neuropathic Pain
Published in
Molecular Pain, January 2009
DOI 10.1186/1744-8069-5-35
Pubmed ID
Authors

Leonardo Guasti, Denise Richardson, Maulik Jhaveri, Khalil Eldeeb, David Barrett, Maurice R Elphick, Stephen PH Alexander, David Kendall, Gregory J Michael, Victoria Chapman

Abstract

Activation of spinal microglia contributes to aberrant pain responses associated with neuropathic pain states. Endocannabinoids (ECs) are present in the spinal cord, and inhibit nociceptive processing; levels of ECs may be altered by microglia which modulate the turnover of endocannabinoids in vitro. Here, we investigate the effect of minocycline, an inhibitor of activated microglia, on levels of the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG), and the related compound N-palmitoylethanolamine (PEA), in neuropathic spinal cord. Selective spinal nerve ligation (SNL) in rats resulted in mechanical allodynia and the presence of activated microglia in the ipsilateral spinal cord. Chronic daily treatment with minocycline (30 mg/kg, ip for 14 days) significantly reduced the development of mechanical allodynia at days 5, 10 and 14 post-SNL surgery, compared to vehicle-treated SNL rats (P < 0.001). Minocycline treatment also significantly attenuated OX-42 immunoreactivity, a marker of activated microglia, in the ipsilateral (P < 0.001) and contralateral (P < 0.01) spinal cord of SNL rats, compared to vehicle controls. Minocycline treatment significantly (P < 0.01) decreased levels of 2-AG and significantly (P < 0.01) increased levels of PEA in the ipsilateral spinal cord of SNL rats, compared to the contralateral spinal cord. Thus, activation of microglia affects spinal levels of endocannabinoids and related compounds in neuropathic pain states.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 2 2%
Iran, Islamic Republic of 1 1%
Romania 1 1%
Unknown 92 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 19%
Researcher 16 16%
Student > Bachelor 10 10%
Student > Master 10 10%
Student > Doctoral Student 9 9%
Other 23 23%
Unknown 11 11%
Readers by discipline Count As %
Medicine and Dentistry 26 27%
Agricultural and Biological Sciences 24 24%
Neuroscience 14 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Psychology 5 5%
Other 9 9%
Unknown 13 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2013.
All research outputs
#1,183,739
of 12,552,259 outputs
Outputs from Molecular Pain
#17
of 464 outputs
Outputs of similar age
#15,689
of 146,729 outputs
Outputs of similar age from Molecular Pain
#1
of 16 outputs
Altmetric has tracked 12,552,259 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 464 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,729 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.