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Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Overview of attention for article published in Revista Brasileira de Psiquiatria, October 2016
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Title
Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
Published in
Revista Brasileira de Psiquiatria, October 2016
DOI 10.1590/1516-4446-2016-1910
Pubmed ID
Authors

Florencia M. Barbé-Tuana, Mariana M. Parisi, Bruna S. Panizzutti, Gabriel R. Fries, Lucas K. Grun, Fátima T. Guma, Flávio Kapczinski, Michael Berk, Clarissa S. Gama, Adriane R. Rosa

Abstract

Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 104 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 13%
Student > Doctoral Student 13 13%
Student > Bachelor 13 13%
Researcher 11 11%
Student > Ph. D. Student 9 9%
Other 20 19%
Unknown 24 23%
Readers by discipline Count As %
Medicine and Dentistry 21 20%
Psychology 12 12%
Biochemistry, Genetics and Molecular Biology 11 11%
Nursing and Health Professions 6 6%
Immunology and Microbiology 5 5%
Other 19 18%
Unknown 30 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2018.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Revista Brasileira de Psiquiatria
#531
of 902 outputs
Outputs of similar age
#209,007
of 323,025 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#5
of 9 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 902 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.