Title |
ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study
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Published in |
Acta Neuropathologica Communications, May 2013
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DOI | 10.1186/2051-5960-1-10 |
Pubmed ID | |
Authors |
Corinne Bouvier, François Bertucci, Philippe Métellus, Pascal Finetti, André Maues de Paula, Fabien Forest, Karima Mokhtari, Catherine Miquel, Daniel Birnbaum, Alexandre Vasiljevic, Anne Jouvet, Jean-Michel Coindre, Anderson Loundou, Dominique Figarella-Branger |
Abstract |
Solitary Fibrous Tumours (SFT) and haemangiopericytomas (HPC) are rare meningeal tumours that have to be distinguished from meningiomas and more rarely from synovial sarcomas. We recently found that ALDH1A1 was overexpressed in SFT and HPC as compared to soft tissue sarcomas. Using whole-genome DNA microarrays, we defined the gene expression profiles of 16 SFT/HPC (9 HPC and 7 SFT). Expression profiles were compared to publicly available expression profiles of additional SFT or HPC, meningiomas and synovial sarcomas. We also performed an immunohistochemical (IHC) study with anti-ALDH1 and anti-CD34 antibodies on Tissue Micro-Arrays including 38 SFT (25 meningeal and 13 extrameningeal), 55 meningeal haemangiopericytomas (24 grade II, 31 grade III), 163 meningiomas (86 grade I, 62 grade II, 15 grade III) and 98 genetically confirmed synovial sarcomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 13% |
Student > Bachelor | 2 | 13% |
Other | 1 | 7% |
Lecturer | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 6 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 27% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Immunology and Microbiology | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Unknown | 8 | 53% |