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Antibacterial activities of almond skins on cagA-positive and-negative clinical isolates of Helicobacter pylori

Overview of attention for article published in BMC Microbiology, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
1 blog
twitter
6 X users
facebook
1 Facebook page

Citations

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39 Dimensions

Readers on

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48 Mendeley
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Title
Antibacterial activities of almond skins on cagA-positive and-negative clinical isolates of Helicobacter pylori
Published in
BMC Microbiology, May 2013
DOI 10.1186/1471-2180-13-103
Pubmed ID
Authors

Carlo Bisignano, Angela Filocamo, Erminia La Camera, Sebastiana Zummo, Maria Teresa Fera, Giuseppina Mandalari

Abstract

BACKGROUND: Helicobacter pylori is known to be a gastric pathogen of humans. Eradication regimens for H. pylori infection have some side effects, compliance problems, relapses, and antibiotic resistance. Therefore, the need for alternative therapies for H. pylori infections is of special interest. We have previously shown that polyphenols from almond skins are active against a range of food-borne pathogens. The aim of this study was to evaluate the antibacterial effects of natural almond skins before and after simulated human digestion and the pure flavonoid compounds epicatechin, naringenin and protocatechuic acid against H. pylori. RESULTS: H. pylori strains were isolated from gastric biopsy samples following standard microbiology procedures. Also, cagA and vacA genes were identified using PCR. Susceptibility studies on 34 strains of H. pylori, including two reference strains (ATCC 43504, ATCC 49503), were performed by the standard agar dilution method.Natural almond skin was the most effective compound against H. pylori (MIC range, 64 to 128 mug/ml), followed by natural skin post gastric digestion (MIC range, 128 to 512 mug/ml), and natural almond skin post gastric plus duodenal digestion (MIC range, 256 to 512 mug/ml). Amongst the pure flavonoid compounds, protocatechuic acid showed the greatest activity (MIC range, 128 to 512 mug/ml) against H. pylori strains. CONCLUSIONS: The Polyphenols from almond skins were effective in vitro against H. pylori, irrespective of genotype status and could therefore be used in combination with antibiotics as a novel strategy for antibiotic resistance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 15%
Student > Bachelor 6 13%
Student > Master 6 13%
Student > Doctoral Student 5 10%
Student > Ph. D. Student 2 4%
Other 5 10%
Unknown 17 35%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 23%
Medicine and Dentistry 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Veterinary Science and Veterinary Medicine 2 4%
Other 7 15%
Unknown 17 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#2,962,275
of 23,881,329 outputs
Outputs from BMC Microbiology
#232
of 3,286 outputs
Outputs of similar age
#25,145
of 195,592 outputs
Outputs of similar age from BMC Microbiology
#3
of 33 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,286 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,592 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.