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Systems Genetics

Overview of attention for book
Cover of 'Systems Genetics'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Resources for Systems Genetics
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    Chapter 2 Heterogeneous Stock Populations for Analysis of Complex Traits
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    Chapter 3 Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research
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    Chapter 4 GeneNetwork: A Toolbox for Systems Genetics
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    Chapter 5 Complex Trait Analyses of the Collaborative Cross: Tools and Databases
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    Chapter 6 Integrative Functional Genomics for Systems Genetics in GeneWeaver.org
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    Chapter 7 A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel
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    Chapter 8 Expression QTLs Mapping and Analysis: A Bayesian Perspective
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    Chapter 9 Epigenetics and Control of RNAs
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    Chapter 10 Integrating Multidimensional Data Sources to Identify Genes Regulating Complex Phenotypes
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    Chapter 11 RNA-Seq in the Collaborative Cross
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    Chapter 12 QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment
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    Chapter 13 Visualization of Results from Systems Genetics Studies in Chromosomal Context
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    Chapter 14 Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits
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    Chapter 15 Precise Network Modeling of Systems Genetics Data Using the Bayesian Network Webserver
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    Chapter 16 Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease
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    Chapter 17 Genomic Control of Retinal Cell Number: Challenges, Protocol, and Results
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    Chapter 18 Systems Genetics Analysis to Identify the Genetic Modulation of a Glaucoma-Associated Gene
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    Chapter 19 Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse
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    Chapter 20 Complex Genetics of Cardiovascular Traits in Mice: F2-Mapping of QTLs and Their Underlying Genes
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    Chapter 21 Systems Genetics of Liver Fibrosis
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    Chapter 22 Systems Genetics Analysis of Iron and Its Regulation in Brain and Periphery
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    Chapter 23 Systems Genetics of Obesity
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    Chapter 24 Social Interactions and Indirect Genetic Effects on Complex Juvenile and Adult Traits
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    Chapter 25 Complex Genetics of Behavior: BXDs in the Automated Home-Cage
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    Chapter 26 Integrative Analysis of Genetic, Genomic, and Phenotypic Data for Ethanol Behaviors: A Network-Based Pipeline for Identifying Mechanisms and Potential Drug Targets
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    Chapter 27 Dissection of Host Susceptibility to Bacterial Infections and Its Toxins
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    Chapter 28 The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
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    Chapter 29 Using Systems Genetics to Understanding the Etiology of Complex Disease
Attention for Chapter 7: A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel
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Chapter title
A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel
Chapter number 7
Book title
Systems Genetics
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6427-7_7
Pubmed ID
Book ISBNs
978-1-4939-6425-3, 978-1-4939-6427-7
Authors

Christoph D. Rau, Mete Civelek, Calvin Pan, Aldons J. Lusis, Rau, Christoph D, Civelek, Mete, Pan, Calvin, Lusis, Aldons J

Editors

Klaus Schughart, Robert W. Williams

Abstract

In this chapter we address the recent explosion in large multilevel population studies such as the METSIM study in humans as well as large panels of animal models such as the Hybrid Mouse Diversity Panel or the BXD set of recombinant inbred strains. These studies have harnessed the increasing affordability of large-scale high-throughput profiling to gather massive quantities of data. These datasets, spread across different -omics levels (genome, transcriptome, etc.), different tissues (e.g. heart, plasma, bone) and different environmental factors (e.g. diet, drugs) each individually have led to a number of novel findings relevant to a variety of complex diseases and other phenotypes. The analysis of these results, however, is often limited to individuals with a comprehensive understanding of database languages such as SQL. In this chapter, we describe the development of a GUI-based database analysis suite, using the Hybrid Mouse Diversity Panel as an example to lay out a series of methods for visualization and integration of large systems genetics datasets. The database is based on the Shiny suite of tools in R, and is transferrable to other SQL-based datasets.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 14%
Professor 1 14%
Student > Ph. D. Student 1 14%
Researcher 1 14%
Professor > Associate Professor 1 14%
Other 1 14%
Unknown 1 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%
Neuroscience 1 14%
Medicine and Dentistry 1 14%
Unknown 2 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2016.
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#15,402,296
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Outputs from Methods in molecular biology
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Outputs of similar age from Methods in molecular biology
#466
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