Chapter title |
Complex Genetics of Cardiovascular Traits in Mice: F2-Mapping of QTLs and Their Underlying Genes
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Chapter number | 20 |
Book title |
Systems Genetics
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Published in |
Methods in molecular biology, January 2017
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DOI | 10.1007/978-1-4939-6427-7_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6425-3, 978-1-4939-6427-7
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Authors |
Svitlana Podliesna, Connie R. Bezzina, Elisabeth M. Lodder |
Editors |
Klaus Schughart, Robert W. Williams |
Abstract |
In this chapter, we will use the example of the identification of Tnni3k as a modulator of cardiac conduction to introduce you to the use of a murine F2-generation intercross as a powerful method for the identification of novel genes relevant for cardiovascular traits. Murine F2-progeny is a genetically diverse panel of mice with differences in phenotype manifestations, e.g. cardiovascular traits such as cardiomyopathy and ECG parameters. This chapter discusses the best strategies for using F2-mice for genetic mapping. Moreover, we provide an example of the feasibility of identification of new genes modulating cardiac function utilizing the technique of mapping quantitative trait loci (QTLs) and a systems genetics integration of available genetic, gene expression, and phenotypic data. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 29% |
Researcher | 1 | 14% |
Lecturer | 1 | 14% |
Other | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 29% |
Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Unknown | 4 | 57% |