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Intracellular insulin in human tumors: examples and implications

Overview of attention for article published in Diabetology & Metabolic Syndrome, April 2011
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Mentioned by

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1 tweeter

Citations

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4 Dimensions

Readers on

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13 Mendeley
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Title
Intracellular insulin in human tumors: examples and implications
Published in
Diabetology & Metabolic Syndrome, April 2011
DOI 10.1186/1758-5996-3-5
Pubmed ID
Authors

Razvan T Radulescu

Abstract

Insulin is one of the major metabolic hormones regulating glucose homeostasis in the organism and a key growth factor for normal and neoplastic cells. Work conducted primarily over the past 3 decades has unravelled the presence of insulin in human breast cancer tissues and, more recently, in human non-small cell lung carcinomas (NSCLC). These findings have suggested that intracellular insulin is involved in the development of these highly prevalent human tumors. A potential mechanism for such involvement is insulin's binding and inactivation of the retinoblastoma tumor suppressor protein (RB) which in turn is likely controlled by insulin-degrading enzyme (IDE). This model and its supporting data are collectively covered in this survey in order to provide further insight into insulin-driven oncogenesis and its reversal through future anticancer therapeutics.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 38%
Professor > Associate Professor 3 23%
Researcher 2 15%
Student > Bachelor 1 8%
Other 1 8%
Other 1 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 38%
Medicine and Dentistry 3 23%
Biochemistry, Genetics and Molecular Biology 2 15%
Unspecified 2 15%
Immunology and Microbiology 1 8%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2013.
All research outputs
#7,807,927
of 12,445,334 outputs
Outputs from Diabetology & Metabolic Syndrome
#199
of 377 outputs
Outputs of similar age
#78,034
of 145,324 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#4
of 5 outputs
Altmetric has tracked 12,445,334 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 377 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 145,324 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.