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Preferential Adhesion Mediated by Hibris and Roughest Regulates Morphogenesis and Patterning in the Drosophila Eye

Overview of attention for article published in Developmental Cell, June 2005
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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1 patent
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Citations

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103 Dimensions

Readers on

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58 Mendeley
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Title
Preferential Adhesion Mediated by Hibris and Roughest Regulates Morphogenesis and Patterning in the Drosophila Eye
Published in
Developmental Cell, June 2005
DOI 10.1016/j.devcel.2005.03.011
Pubmed ID
Authors

Sujin Bao, Ross Cagan

Abstract

Cell adhesion is essential for morphogenesis; however, the mechanisms by which cell adhesion coordinates precisely regulated morphogenesis are poorly understood. Here we analyze the morphogenetic processes that organize the interommatidial precursor cells (IPCs) of the Drosophila pupal eye. We demonstrate that the Drosophila immunoglobulin superfamily members Hibris and Roughest are essential for IPC morphogenesis in the eye. The two loci are expressed in complementary cell types, and Hibris and Roughest proteins bind directly in vivo. Primary pigment cells employ Hibris to function as organizers in this process; IPCs minimize contacts with neighboring IPCs and utilize Roughest to maximize contacts with primaries. In addition, we provide evidence that interactions between Hibris and Roughest promote junction formation and that levels of Roughest in individual cells determine their capacity for competition. Our results demonstrate that preferential adhesion mediated by heterophilic interacting cell-adhesion molecules can create a precise pattern by minimizing surface free energy.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 5%
United Kingdom 1 2%
France 1 2%
Spain 1 2%
Korea, Republic of 1 2%
Unknown 51 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 31%
Researcher 17 29%
Student > Master 6 10%
Professor 4 7%
Student > Bachelor 4 7%
Other 9 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 59%
Biochemistry, Genetics and Molecular Biology 9 16%
Engineering 7 12%
Medicine and Dentistry 3 5%
Physics and Astronomy 2 3%
Other 3 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2010.
All research outputs
#3,151,291
of 12,452,386 outputs
Outputs from Developmental Cell
#1,139
of 2,904 outputs
Outputs of similar age
#3,050,426
of 11,884,136 outputs
Outputs of similar age from Developmental Cell
#1,135
of 2,872 outputs
Altmetric has tracked 12,452,386 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 11,884,136 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 2,872 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.