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The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

Overview of attention for article published in EMBO Journal, May 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
patent
6 patents

Citations

dimensions_citation
443 Dimensions

Readers on

mendeley
340 Mendeley
citeulike
4 CiteULike
Title
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
Published in
EMBO Journal, May 2011
DOI 10.1038/emboj.2011.158
Pubmed ID
Authors

Charles E Massie, Andy Lynch, Antonio Ramos-Montoya, Joan Boren, Rory Stark, Ladan Fazli, Anne Warren, Helen Scott, Basetti Madhu, Naomi Sharma, Helene Bon, Vinny Zecchini, Donna-Michelle Smith, Gina M DeNicola, Nik Mathews, Michelle Osborne, James Hadfield, Stewart MacArthur, Boris Adryan, Scott K Lyons, Kevin M Brindle, John Griffiths, Martin E Gleave, Paul S Rennie, David E Neal, Ian G Mills

Abstract

The androgen receptor (AR) is a key regulator of prostate growth and the principal drug target for the treatment of prostate cancer. Previous studies have mapped AR targets and identified some candidates which may contribute to cancer progression, but did not characterize AR biology in an integrated manner. In this study, we took an interdisciplinary approach, integrating detailed genomic studies with metabolomic profiling and identify an anabolic transcriptional network involving AR as the core regulator. Restricting flux through anabolic pathways is an attractive approach to deprive tumours of the building blocks needed to sustain tumour growth. Therefore, we searched for targets of the AR that may contribute to these anabolic processes and could be amenable to therapeutic intervention by virtue of differential expression in prostate tumours. This highlighted calcium/calmodulin-dependent protein kinase kinase 2, which we show is overexpressed in prostate cancer and regulates cancer cell growth via its unexpected role as a hormone-dependent modulator of anabolic metabolism. In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by taking an unbiased interdisciplinary approach.

Mendeley readers

The data shown below were compiled from readership statistics for 340 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 6 2%
Brazil 2 <1%
Portugal 1 <1%
Chile 1 <1%
India 1 <1%
Germany 1 <1%
Czechia 1 <1%
Canada 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 324 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 75 22%
Researcher 69 20%
Other 31 9%
Student > Master 30 9%
Student > Bachelor 30 9%
Other 54 16%
Unknown 51 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 91 27%
Biochemistry, Genetics and Molecular Biology 81 24%
Medicine and Dentistry 49 14%
Computer Science 11 3%
Pharmacology, Toxicology and Pharmaceutical Science 10 3%
Other 41 12%
Unknown 57 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2021.
All research outputs
#2,424,887
of 20,858,036 outputs
Outputs from EMBO Journal
#1,418
of 12,177 outputs
Outputs of similar age
#20,746
of 172,037 outputs
Outputs of similar age from EMBO Journal
#9
of 57 outputs
Altmetric has tracked 20,858,036 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,177 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,037 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.