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Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, May 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
114 Mendeley
Title
Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
Published in
Proceedings of the National Academy of Sciences of the United States of America, May 2011
DOI 10.1073/pnas.1018863108
Pubmed ID
Authors

Kelly A. Holmes, Antoni Hurtado, Gordon D. Brown, Rosalind Launchbury, Caryn S. Ross-Innes, James Hadfield, Duncan T. Odom, Jason S. Carroll

Abstract

Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin interactions, a role that is distinct from its general role as a transcriptional repressor. We show that specific silencing of TLE1 inhibits the ability of ER to bind to a subset of ER binding sites within the genome, a phenomenon that results in perturbations in phospho-RNA Pol II recruitment. Furthermore, TLE1 is essential for effective ER-mediated cell division. We have discovered a distinct role for TLE1, as a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions.

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Latvia 1 <1%
United States 1 <1%
Italy 1 <1%
Unknown 111 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 35 31%
Other 32 28%
Student > Ph. D. Student 17 15%
Student > Bachelor 6 5%
Professor > Associate Professor 6 5%
Other 9 8%
Unknown 9 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 73 64%
Biochemistry, Genetics and Molecular Biology 13 11%
Medicine and Dentistry 6 5%
Computer Science 4 4%
Chemistry 3 3%
Other 4 4%
Unknown 11 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2016.
All research outputs
#4,468,465
of 17,359,532 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#6,879
of 31,886 outputs
Outputs of similar age
#39,122
of 162,423 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#76
of 221 outputs
Altmetric has tracked 17,359,532 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 31,886 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,423 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 221 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.