Title |
The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi
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Published in |
BMC Microbiology, January 2010
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DOI | 10.1186/1471-2180-10-21 |
Pubmed ID | |
Authors |
Ryan G Rhodes, Janet A Atoyan, David R Nelson |
Abstract |
The bacterium Borrelia burgdorferi, the causative agent of Lyme disease, is a limited-genome organism that must obtain many of its biochemical building blocks, including N-acetylglucosamine (GlcNAc), from its tick or vertebrate host. GlcNAc can be imported into the cell as a monomer or dimer (chitobiose), and the annotation for several B. burgdorferi genes suggests that this organism may be able to degrade and utilize chitin, a polymer of GlcNAc. We investigated the ability of B. burgdorferi to utilize chitin in the absence of free GlcNAc, and we attempted to identify genes involved in the process. We also examined the role of RpoS, one of two alternative sigma factors present in B. burgdorferi, in the regulation of chitin utilization. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 32 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 24% |
Student > Ph. D. Student | 6 | 18% |
Student > Doctoral Student | 4 | 12% |
Student > Master | 4 | 12% |
Other | 2 | 6% |
Other | 5 | 15% |
Unknown | 4 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 45% |
Biochemistry, Genetics and Molecular Biology | 5 | 15% |
Immunology and Microbiology | 3 | 9% |
Medicine and Dentistry | 2 | 6% |
Chemical Engineering | 1 | 3% |
Other | 2 | 6% |
Unknown | 5 | 15% |