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Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile

Overview of attention for article published in BMC Medicine, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

1 blog
22 tweeters
1 Wikipedia page


344 Dimensions

Readers on

555 Mendeley
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Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile
Published in
BMC Medicine, May 2013
DOI 10.1186/1741-7015-11-129
Pubmed ID

Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs


Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has been shown to subsequently increase the risk of, for example, cardiovascular, stroke, diabetes and obesity morbidity. These somatic consequences could partly be due to metabolic, immuno-inflammatory, autonomic and hypothalamic-pituitary-adrenal (HPA)-axis dysregulations which have been suggested to be more often present among depressed patients. Evidence linking depression to metabolic syndrome abnormalities indicates that depression is especially associated with its obesity-related components (for example, abdominal obesity and dyslipidemia). In addition, systemic inflammation and hyperactivity of the HPA-axis have been consistently observed among depressed patients. Slightly less consistent observations are for autonomic dysregulation among depressed patients. The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. This review finishes with potential treatment implications for the downward spiral in which different depressive symptom profiles and biological dysregulations may impact on each other and interact with somatic health decline.

Twitter Demographics

The data shown below were collected from the profiles of 22 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 555 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
Spain 3 <1%
United Kingdom 2 <1%
India 2 <1%
Brazil 1 <1%
Netherlands 1 <1%
Switzerland 1 <1%
Portugal 1 <1%
Unknown 540 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 118 21%
Student > Master 88 16%
Student > Ph. D. Student 85 15%
Researcher 49 9%
Student > Doctoral Student 36 6%
Other 114 21%
Unknown 65 12%
Readers by discipline Count As %
Medicine and Dentistry 166 30%
Psychology 89 16%
Agricultural and Biological Sciences 53 10%
Neuroscience 34 6%
Biochemistry, Genetics and Molecular Biology 28 5%
Other 86 15%
Unknown 99 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2020.
All research outputs
of 16,242,345 outputs
Outputs from BMC Medicine
of 2,559 outputs
Outputs of similar age
of 158,138 outputs
Outputs of similar age from BMC Medicine
of 1 outputs
Altmetric has tracked 16,242,345 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,559 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,138 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them