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Modern Proteomics – Sample Preparation, Analysis and Practical Applications

Overview of attention for book
Cover of 'Modern Proteomics – Sample Preparation, Analysis and Practical Applications'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Proteomes, Their Compositions and Their Sources
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    Chapter 2 Protein Fractionation and Enrichment Prior to Proteomics Sample Preparation
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    Chapter 3 Sample Preparation for Mass Spectrometry-Based Proteomics; from Proteomes to Peptides
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    Chapter 4 Plant Structure and Specificity – Challenges and Sample Preparation Considerations for Proteomics
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    Chapter 5 Improving Proteome Coverage by Reducing Sample Complexity via Chromatography
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    Chapter 6 Database Search Engines: Paradigms, Challenges and Solutions
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    Chapter 7 Mass Analyzers and Mass Spectrometers
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    Chapter 8 Top-Down Mass Spectrometry: Proteomics to Proteoforms
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    Chapter 9 Platforms and Pipelines for Proteomics Data Analysis and Management
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    Chapter 10 Tandem Mass Spectrum Sequencing: An Alternative to Database Search Engines in Shotgun Proteomics
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    Chapter 11 Visualization, Inspection and Interpretation of Shotgun Proteomics Identification Results
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    Chapter 12 Protein Inference
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    Chapter 13 Modification Site Localization in Peptides
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    Chapter 14 Useful Web Resources
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    Chapter 15 Mass Spectrometry-Based Protein Quantification
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    Chapter 16 Bioinformatics Tools for Proteomics Data Interpretation
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    Chapter 17 Identification, Quantification, and Site Localization of Protein Posttranslational Modifications via Mass Spectrometry-Based Proteomics
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    Chapter 18 Protein-Protein Interaction Detection Via Mass Spectrometry-Based Proteomics
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    Chapter 19 Protein Structural Analysis via Mass Spectrometry-Based Proteomics
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    Chapter 20 Introduction to Clinical Proteomics
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    Chapter 21 Discovery of Candidate Biomarkers
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    Chapter 22 Statistical Approaches to Candidate Biomarker Panel Selection
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    Chapter 23 Qualification and Verification of Protein Biomarker Candidates
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    Chapter 24 Protocol for Standardizing High-to-Moderate Abundance Protein Biomarker Assessments Through an MRM-with-Standard-Peptides Quantitative Approach
Attention for Chapter 19: Protein Structural Analysis via Mass Spectrometry-Based Proteomics
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Chapter title
Protein Structural Analysis via Mass Spectrometry-Based Proteomics
Chapter number 19
Book title
Modern Proteomics – Sample Preparation, Analysis and Practical Applications
Published in
Advances in experimental medicine and biology, December 2016
DOI 10.1007/978-3-319-41448-5_19
Pubmed ID
27975228
Book ISBNs
978-3-31-941446-1, 978-3-31-941448-5
Authors

Antonio Artigues, Owen W. Nadeau, Mary Ashley Rimmer, Maria T. Villar, Xiuxia Du, Aron W. Fenton, Gerald M. Carlson

Editors

Hamid Mirzaei, Martin Carrasco

Abstract

Modern mass spectrometry (MS) technologies have provided a versatile platform that can be combined with a large number of techniques to analyze protein structure and dynamics. These techniques include the three detailed in this chapter: (1) hydrogen/deuterium exchange (HDX), (2) limited proteolysis, and (3) chemical crosslinking (CX). HDX relies on the change in mass of a protein upon its dilution into deuterated buffer, which results in varied deuterium content within its backbone amides. Structural information on surface exposed, flexible or disordered linker regions of proteins can be achieved through limited proteolysis, using a variety of proteases and only small extents of digestion. CX refers to the covalent coupling of distinct chemical species and has been used to analyze the structure, function and interactions of proteins by identifying crosslinking sites that are formed by small multi-functional reagents, termed crosslinkers. Each of these MS applications is capable of revealing structural information for proteins when used either with or without other typical high resolution techniques, including NMR and X-ray crystallography.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 26%
Student > Bachelor 11 16%
Researcher 6 9%
Student > Master 6 9%
Other 4 6%
Other 7 10%
Unknown 16 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 38%
Chemistry 6 9%
Agricultural and Biological Sciences 6 9%
Engineering 3 4%
Computer Science 2 3%
Other 8 12%
Unknown 17 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2022.
All research outputs
#19,015,492
of 23,577,654 outputs
Outputs from Advances in experimental medicine and biology
#3,405
of 5,040 outputs
Outputs of similar age
#313,345
of 424,296 outputs
Outputs of similar age from Advances in experimental medicine and biology
#340
of 500 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,040 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 500 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.

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