Title |
Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles
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Published in |
Cell, May 2013
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DOI | 10.1016/j.cell.2013.04.029 |
Pubmed ID | |
Authors |
Neta Regev-Rudzki, Danny W. Wilson, Teresa G. Carvalho, Xavier Sisquella, Bradley M. Coleman, Melanie Rug, Dejan Bursac, Fiona Angrisano, Michelle Gee, Andrew F. Hill, Jake Baum, Alan F. Cowman |
Abstract |
Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation. We determined that Plasmodium falciparum-infected red blood cells directly communicate between parasites within a population using exosome-like vesicles that are capable of delivering genes. Importantly, communication via exosome-like vesicles promotes differentiation to sexual forms at a rate that suggests that signaling is involved. Furthermore, we have identified a P. falciparum protein, PfPTP2, that plays a key role in efficient communication. This study reveals a previously unidentified pathway of P. falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 24% |
United Kingdom | 3 | 6% |
Israel | 2 | 4% |
France | 2 | 4% |
Spain | 1 | 2% |
Canada | 1 | 2% |
Côte d'Ivoire | 1 | 2% |
Netherlands | 1 | 2% |
Australia | 1 | 2% |
Other | 7 | 14% |
Unknown | 18 | 37% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 37 | 76% |
Scientists | 8 | 16% |
Science communicators (journalists, bloggers, editors) | 3 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | <1% |
India | 4 | <1% |
France | 4 | <1% |
United Kingdom | 4 | <1% |
Brazil | 3 | <1% |
Kenya | 2 | <1% |
Belgium | 2 | <1% |
Canada | 2 | <1% |
Australia | 1 | <1% |
Other | 7 | <1% |
Unknown | 724 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 189 | 25% |
Researcher | 135 | 18% |
Student > Master | 81 | 11% |
Student > Bachelor | 69 | 9% |
Student > Doctoral Student | 40 | 5% |
Other | 114 | 15% |
Unknown | 130 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 277 | 37% |
Biochemistry, Genetics and Molecular Biology | 159 | 21% |
Immunology and Microbiology | 52 | 7% |
Medicine and Dentistry | 43 | 6% |
Engineering | 15 | 2% |
Other | 67 | 9% |
Unknown | 145 | 19% |