Chapter title |
Recurrent Cytogenetic Abnormalities in Acute Myeloid Leukemia.
|
---|---|
Chapter number | 19 |
Book title |
Cancer Cytogenetics
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6703-2_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6701-8, 978-1-4939-6703-2
|
Authors |
John J. Yang, Tae Sung Park, Thomas S. K. Wan |
Editors |
Thomas S.K. Wan |
Abstract |
The spectrum of chromosomal abnormality associated with leukemogenesis of acute myeloid leukemia (AML) is broad and heterogeneous when compared to chronic myeloid leukemia and other myeloid neoplasms. Recurrent chromosomal translocations such as t(8;21), t(15;17), and inv(16) are frequently detected, but hundreds of other uncommon chromosomal aberrations from AML also exist. This chapter discusses 22 chromosomal abnormalities that are common structural, numerical aberrations, and other important but infrequent (less than 1 %) translocations emphasized in the WHO classification. Brief morphologic, cytogenetic, and clinical characteristics are summarized, so as to provide a concise reference to cancer cytogenetic laboratories. Morphology based on FAB classification is used together with the current WHO classification due to frequent mentioning in a vast number of reference literatures. Characteristic chromosomal aberrations of other myeloid neoplasms such as myelodysplastic syndrome and myeloproliferative neoplasm will be discussed in separate chapters-except for certain abnormalities such as t(9;22) in de novo AML. Gene mutations detected in normal karyotype AML by cutting edge next generation sequencing technology are also briefly mentioned. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 19% |
Student > Ph. D. Student | 9 | 14% |
Student > Master | 6 | 10% |
Researcher | 4 | 6% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 13% |
Unknown | 21 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 19 | 30% |
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Agricultural and Biological Sciences | 4 | 6% |
Immunology and Microbiology | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 1 | 2% |
Unknown | 24 | 38% |