mTOR

Table of Contents

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   Book Overview
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   Chapter 1 Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life.
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   Chapter 2 Biochemical and Pharmacological Inhibition of mTOR by Rapamycin and an ATP-Competitive mTOR Inhibitor.
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   Chapter 3 Evaluation of the Nutrient-Sensing mTOR Pathway.
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   Chapter 4 mTOR Activity Under Hypoxia.
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   Chapter 5 Isolation of the mTOR Complexes by Affinity Purification.
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   Chapter 6 An In Vitro Assay for the Kinase Activity of mTOR Complex 2
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   Chapter 7 Overexpression or Downregulation of mTOR in Mammalian Cells.
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   Chapter 8 Detection of Cytoplasmic and Nuclear Functions of mTOR by Fractionation.
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    Chapter 9 Evaluation of rapamycin-induced cell death.
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    Chapter 10 Evaluation of mTOR-Regulated mRNA Translation
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    Chapter 11 A Genome-wide RNAi Screen for Polypeptides that Alter rpS6 Phosphorylation.
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    Chapter 12 Immunohistochemical Analysis of mTOR Activity in Tissues.
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    Chapter 13 Assessing Cell Size and Cell Cycle Regulation in Cells with Altered TOR Activity.
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    Chapter 14 Quantitative Visualization of Autophagy Induction by mTOR Inhibitors.
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    Chapter 15 The In Vivo Evaluation of Active-Site TOR Inhibitors in Models of BCR-ABL+ Leukemia.
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    Chapter 16 Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts.
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    Chapter 17 Expanding Human T Regulatory Cells with the mTOR-Inhibitor Rapamycin.
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    Chapter 18 Rapamycin-induced enhancement of vaccine efficacy in mice.
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    Chapter 19 Utilizing a Retroviral RNAi System to Investigate In Vivo mTOR Functions in T Cells.
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    Chapter 20 Exploring Functional In Vivo Consequences of the Selective Genetic Ablation of mTOR Signaling in T Helper Lymphocytes.
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    Chapter 21 Evaluating the Therapeutic Potential of mTOR Inhibitors Using Mouse Genetics.
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    Chapter 22 Inhibition of PI3K-Akt-mTOR Signaling in Glioblastoma by mTORC1/2 Inhibitors.
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    Chapter 23 Assessing the Function of mTOR in Human Embryonic Stem Cells.
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    Chapter 24 Video-EEG Monitoring Methods for Characterizing Rodent Models of Tuberous Sclerosis and Epilepsy.
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    Chapter 25 A Genetic Model to Dissect the Role of Tsc-mTORC1 in Neuronal Cultures.
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    Chapter 26 Tissue-specific ablation of tsc1 in pancreatic Beta-cells.
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    Chapter 27 A Mouse Model of Diet-Induced Obesity and Insulin Resistance
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    Chapter 28 Rapamycin as immunosuppressant in murine transplantation model.
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    Chapter 29 Development of ATP-Competitive mTOR Inhibitors.