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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

Overview of attention for article published in Molecular Cancer, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

twitter
7 tweeters
patent
1 patent

Citations

dimensions_citation
76 Dimensions

Readers on

mendeley
62 Mendeley
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Title
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak
Published in
Molecular Cancer, May 2013
DOI 10.1186/1476-4598-12-42
Pubmed ID
Authors

Xiaobo Cao, Jeremy L Yap, M Karen Newell-Rogers, Chander Peddaboina, Weihua Jiang, Harry T Papaconstantinou, Dan Jupitor, Arun Rai, Kwan-Young Jung, Richard P Tubin, Wenbo Yu, Kenno Vanommeslaeghe, Paul T Wilder, Alexander D MacKerell, Steven Fletcher, Roy W Smythe

Abstract

It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-2/Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents. We designed the BH3 α-helix mimetic JY-1-106 to engage the hydrophobic BH3-binding grooves on the surfaces of both Bcl-xL and Mcl-1.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United Kingdom 1 2%
Turkey 1 2%
Germany 1 2%
Unknown 58 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 19%
Researcher 10 16%
Student > Bachelor 7 11%
Student > Master 6 10%
Student > Doctoral Student 5 8%
Other 10 16%
Unknown 12 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 24%
Chemistry 12 19%
Biochemistry, Genetics and Molecular Biology 7 11%
Medicine and Dentistry 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Other 7 11%
Unknown 12 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2017.
All research outputs
#3,434,233
of 17,668,039 outputs
Outputs from Molecular Cancer
#158
of 1,386 outputs
Outputs of similar age
#31,934
of 165,311 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 17,668,039 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,386 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,311 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them