Title |
The most transformative drugs of the past 25 years: a survey of physicians
|
---|---|
Published in |
Nature Reviews Drug Discovery, May 2013
|
DOI | 10.1038/nrd3977 |
Pubmed ID | |
Authors |
Aaron S. Kesselheim, Jerry Avorn |
Abstract |
Strategic and legislative efforts to catalyse pharmaceutical innovation may be hampered by a lack of consensus over what characterizes an innovative drug. To help clarify this issue, we conducted an extensive survey on transformative drug development, involving ∼180 expert physicians based at 30 leading US academic medical centres, covering 15 medical specialties. In an iterative Delphi process, the survey participants narrowed a list of all new drugs approved in their fields in the past 25 years and reached consensus over those that they considered to be most transformative, which are presented in this article. Participants were also asked how various factors affected their opinion; they most often invoked the effectiveness and superiority of the drugs over existing alternatives when identifying transformative drug innovation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 20% |
United Kingdom | 6 | 15% |
Germany | 3 | 8% |
Canada | 2 | 5% |
Spain | 1 | 3% |
France | 1 | 3% |
Mexico | 1 | 3% |
Austria | 1 | 3% |
Japan | 1 | 3% |
Other | 3 | 8% |
Unknown | 13 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 22 | 55% |
Scientists | 14 | 35% |
Practitioners (doctors, other healthcare professionals) | 3 | 8% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
United Kingdom | 3 | 2% |
Colombia | 1 | <1% |
Germany | 1 | <1% |
Sri Lanka | 1 | <1% |
Portugal | 1 | <1% |
Greece | 1 | <1% |
Spain | 1 | <1% |
Unknown | 114 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 39 | 31% |
Other | 20 | 16% |
Student > Ph. D. Student | 13 | 10% |
Professor | 12 | 9% |
Student > Bachelor | 10 | 8% |
Other | 27 | 21% |
Unknown | 6 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 27% |
Medicine and Dentistry | 28 | 22% |
Chemistry | 19 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Other | 19 | 15% |
Unknown | 10 | 8% |