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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Population- and Family-Based Studies Associate the MTHFR Gene with Idiopathic Autism in Simplex Families
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, November 2010
|
| DOI | 10.1007/s10803-010-1120-x |
| Pubmed ID | |
| Authors |
Xudong Liu, Fatima Solehdin, Ira L. Cohen, Maripaz G. Gonzalez, Edmund C. Jenkins, M. E. Suzanne Lewis, Jeanette J. A. Holden |
| Abstract |
Two methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphisms were studied in 205 North American simplex (SPX) and 307 multiplex (MPX) families having one or more children with an autism spectrum disorder. Case-control comparisons revealed a significantly higher frequency of the low-activity 677T allele, higher prevalence of the 677TT genotype and higher frequencies of the 677T-1298A haplotype and double homozygous 677TT/1298AA genotype in affected individuals relative to controls. Family-based association testing demonstrated significant preferential transmission of the 677T and 1298A alleles and the 677T-1298A haplotype to affected offspring. The results were not replicated in MPX families. The results associate the MTHFR gene with autism in SPX families only, suggesting that reduced MTHFR activity is a risk factor for autism in these families. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 57 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 17% |
| Researcher | 8 | 14% |
| Student > Master | 8 | 14% |
| Other | 7 | 12% |
| Student > Bachelor | 4 | 7% |
| Other | 11 | 19% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 17% |
| Agricultural and Biological Sciences | 8 | 14% |
| Psychology | 7 | 12% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Social Sciences | 4 | 7% |
| Other | 11 | 19% |
| Unknown | 12 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2018.
All research outputs
#15,210,784
of 25,827,956 outputs
Outputs from Journal of Autism and Developmental Disorders
#3,537
of 5,451 outputs
Outputs of similar age
#85,908
of 111,225 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#27
of 32 outputs
Altmetric has tracked 25,827,956 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,225 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.