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Synergistic anti-glioma effect of a coloaded nano-drug delivery system

Overview of attention for article published in International Journal of Nanomedicine, December 2016
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2 tweeters

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Title
Synergistic anti-glioma effect of a coloaded nano-drug delivery system
Published in
International Journal of Nanomedicine, December 2016
DOI 10.2147/ijn.s116367
Pubmed ID
Authors

Huae Xu, Feng Jia, Pankaj Singh, Shu Ruan, Hao Zhang, Xiaolin Li

Abstract

The anti-glioma effect of temozolomide (Tem) is sometimes undermined by the emerging resistance. Recently, resveratrol (Res), herbal medicine extracted from grape seeds, has been demonstrated for its potential use in chemosensitization. In the current study, both these drugs were loaded simultaneously into nanoparticles with methoxy poly(ethylene glycol)-poly epsilon caprolactone (mPEG-PCL) as drug carriers in order to achieve better antitumor efficiency. Tem/Res-coloaded mPEG-PCL nanoparticles were constructed, characterized, and tested for antitumor effect on glioma cells by using in vitro and xenograft model system. The nanoparticle constructs were satisfactory with drug loading content (Res =~12.4%; Tem =~9.3%) and encapsulation capacity of >85% for both the drugs. In addition, the coencapsulation led to better in vitro stability of the nanoparticles than Tem-loaded nanoparticles. An in vitro uptake study demonstrated a high uptake efficiency of the nanoparticles by glioma cells. The synergistic antitumor effect against glioma cells was observed in the combinational treatment of Res and Tem. Tem/Res-coloaded nanoparticles induced higher apoptosis in U87 glioma cells as compared to cells treated by the combination of free drugs. Tem/Res-coloaded particles caused more effective inhibition of phosphor-Akt, leading to upregulation of the downstream apoptotic proteins. In addition, the in vivo study showed the superior tumor delaying effect of coloaded nanoparticles than that of free drug combination. These results suggest that Tem/Res-coloaded nanoparticles could be a potential useful chemotherapeutic formulation for glioma therapy.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Student > Doctoral Student 7 18%
Student > Bachelor 6 15%
Student > Master 5 13%
Researcher 3 8%
Other 7 18%
Unknown 4 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 20%
Pharmacology, Toxicology and Pharmaceutical Science 6 15%
Chemistry 5 13%
Medicine and Dentistry 5 13%
Agricultural and Biological Sciences 2 5%
Other 7 18%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2016.
All research outputs
#17,837,681
of 22,914,829 outputs
Outputs from International Journal of Nanomedicine
#2,751
of 3,826 outputs
Outputs of similar age
#287,772
of 416,479 outputs
Outputs of similar age from International Journal of Nanomedicine
#46
of 68 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,826 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,479 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.