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The effect of subacute co-exposure to carbon tetrachloride and diclofenac on the liver of male wistar rats

Overview of attention for article published in Toxicology and Industrial Health, May 2023
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Title
The effect of subacute co-exposure to carbon tetrachloride and diclofenac on the liver of male wistar rats
Published in
Toxicology and Industrial Health, May 2023
DOI 10.1177/07482337231174994
Pubmed ID
Authors

Zahra Hassanpour, Farshad H Shirazi, Sara Shokrpoor, Rasoul Yarahmadi, Narges Moghadasi, Mehran Vosoogh, Azadeh Ashtarinezhad

Abstract

Carbon tetrachloride (CCl4) is a potent liver toxin. Diclofenac (Dic), leading adverse effects on the liver, is used among the employees of the industries that use CCl4. The increased use of CCl4 and Dic in industrial workers has prompted us to investigate their synergistic effect on the liver using male Wistar rats as a model. Male Wistar rats were divided into seven groups (n = 6), and the exposure was by intraperitoneal injection for 14 days as follows. Group 1: Control, 2: Olive oil, 3: CCl4 (0.8 mL/kg/day (3 times per week)), 4: Normal saline, 5: Dic (1.5 mg/kg/day per day), 6: Olive oil with normal saline, 7: CCl4 (0.8 mL/kg/day (3 times per week)) and Dic (1.5 mg/kg/day daily). At the end of day 14, the heart blood was collected to measure the liver enzymes, alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), blood alkaline phosphatase (ALP), albumin (ALB), direct bilirubin, and total bilirubin. A pathologist examined the liver tissue. Prism software was used to analyze data using ANOVA and Tukey statistical tests. ALT, AST, ALP, and Total Bilirubin enzymes were increased significantly in the co-administered CCl4 and Dic group, while the ALB levels decreased (p < 0.05). The histological findings reported liver necrosis, focal hemorrhage, adipose tissue change, and lymphocytic portal hepatitis. In conclusion, using Dic while exposed to CCl4 may exacerbate hepatotoxicity in rats. Therefore, it is suggested that more severe restrictions and safety regulations be placed on using CCl4 in the industry, and caution is advised to these industry workers to use Diclofenac.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2023.
All research outputs
#21,110,894
of 25,931,626 outputs
Outputs from Toxicology and Industrial Health
#678
of 852 outputs
Outputs of similar age
#293,665
of 396,102 outputs
Outputs of similar age from Toxicology and Industrial Health
#1
of 2 outputs
Altmetric has tracked 25,931,626 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 852 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them