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Archaic adaptive introgression in TBX15/WARS2

Overview of attention for article published in Molecular Biology and Evolution, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 3,699)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
31 news outlets
blogs
9 blogs
twitter
49 tweeters
facebook
3 Facebook pages
googleplus
6 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
135 Mendeley
citeulike
1 CiteULike

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Title
Archaic adaptive introgression in TBX15/WARS2
Published in
Molecular Biology and Evolution, December 2016
DOI 10.1093/molbev/msw283
Pubmed ID
28007980
Authors

Fernando Racimo, David Gokhman, Matteo Fumagalli, Amy Ko, Torben Hansen, Ida Moltke, Anders Albrechtsen, Liran Carmel, Emilia Huerta-Sánchez, Rasmus Nielsen

Abstract

A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15.

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Twitter Demographics

The data shown below were collected from the profiles of 49 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
France 2 1%
Italy 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Portugal 1 <1%
Canada 1 <1%
Unknown 125 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 32%
Researcher 25 19%
Unspecified 17 13%
Student > Master 12 9%
Student > Bachelor 12 9%
Other 26 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 37%
Biochemistry, Genetics and Molecular Biology 38 28%
Unspecified 19 14%
Social Sciences 9 7%
Psychology 4 3%
Other 15 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 327. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2019.
All research outputs
#36,908
of 13,889,642 outputs
Outputs from Molecular Biology and Evolution
#6
of 3,699 outputs
Outputs of similar age
#2,125
of 375,458 outputs
Outputs of similar age from Molecular Biology and Evolution
#2
of 89 outputs
Altmetric has tracked 13,889,642 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,699 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 375,458 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.

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