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Archaic adaptive introgression in TBX15/WARS2

Overview of attention for article published in Molecular Biology and Evolution, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 4,034)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
32 news outlets
blogs
9 blogs
twitter
48 tweeters
facebook
3 Facebook pages
wikipedia
1 Wikipedia page
googleplus
6 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
52 Dimensions

Readers on

mendeley
130 Mendeley
citeulike
1 CiteULike
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Title
Archaic adaptive introgression in TBX15/WARS2
Published in
Molecular Biology and Evolution, December 2016
DOI 10.1093/molbev/msw283
Pubmed ID
Authors

Fernando Racimo, David Gokhman, Matteo Fumagalli, Amy Ko, Torben Hansen, Ida Moltke, Anders Albrechtsen, Liran Carmel, Emilia Huerta-Sánchez, Rasmus Nielsen

Abstract

A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15.

Twitter Demographics

The data shown below were collected from the profiles of 48 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 2%
Japan 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Unknown 125 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 38 29%
Researcher 16 12%
Student > Master 15 12%
Student > Bachelor 14 11%
Other 8 6%
Other 21 16%
Unknown 18 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 31%
Biochemistry, Genetics and Molecular Biology 37 28%
Social Sciences 9 7%
Environmental Science 7 5%
Psychology 4 3%
Other 15 12%
Unknown 18 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 338. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2020.
All research outputs
#45,489
of 15,852,912 outputs
Outputs from Molecular Biology and Evolution
#9
of 4,034 outputs
Outputs of similar age
#2,141
of 386,283 outputs
Outputs of similar age from Molecular Biology and Evolution
#2
of 89 outputs
Altmetric has tracked 15,852,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,034 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 386,283 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.