Report for: Archaic adaptive introgression in TBX15/WARS2

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Title	Archaic adaptive introgression in TBX15/WARS2
Published in	Molecular Biology and Evolution, December 2016
DOI	10.1093/molbev/msw283
Pubmed ID	28007980
Authors	Fernando Racimo, David Gokhman, Matteo Fumagalli, Amy Ko, Torben Hansen, Ida Moltke, Anders Albrechtsen, Liran Carmel, Emilia Huerta-Sánchez, Rasmus Nielsen
Abstract	A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15.

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Twitter Demographics

The data shown below were collected from the profiles of 49 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	13	27%
United Kingdom	4	8%
Spain	3	6%
France	2	4%
Germany	2	4%
Japan	1	2%
Netherlands	1	2%
Italy	1	2%
New Zealand	1	2%
Other	7	14%
Unknown	14	29%

Demographic breakdown

Type	Count	As %
Scientists	25	51%
Members of the public	21	43%
Practitioners (doctors, other healthcare professionals)	3	6%

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	3	2%
France	2	1%
Italy	1	<1%
United Kingdom	1	<1%
Japan	1	<1%
Portugal	1	<1%
Canada	1	<1%
Unknown	125	93%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	43	32%
Researcher	25	19%
Unspecified	17	13%
Student > Master	12	9%
Student > Bachelor	12	9%
Other	26	19%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	50	37%
Biochemistry, Genetics and Molecular Biology	38	28%
Unspecified	19	14%
Social Sciences	9	7%
Psychology	4	3%
Other	15	11%

Attention Score in Context

This research output has an Altmetric Attention Score of 327. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2019.

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#36,830

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Outputs from Molecular Biology and Evolution

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#2,126

of 375,319 outputs

Outputs of similar age from Molecular Biology and Evolution

of 89 outputs

Altmetric has tracked 13,852,496 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 3,694 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has done particularly well, scoring higher than 99% of its peers.

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Archaic adaptive introgression in TBX15/WARS2

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