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High resolution 3D imaging of living cells with sub-optical wavelength phonons

Overview of attention for article published in Scientific Reports, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
21 news outlets
blogs
1 blog
twitter
22 X users
facebook
3 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
82 Mendeley
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Title
High resolution 3D imaging of living cells with sub-optical wavelength phonons
Published in
Scientific Reports, December 2016
DOI 10.1038/srep39326
Pubmed ID
Authors

Fernando Pérez-Cota, Richard J. Smith, Emilia Moradi, Leonel Marques, Kevin F. Webb, Matt Clark

Abstract

Label-free imaging of living cells below the optical diffraction limit poses great challenges for optical microscopy. Biologically relevant structural information remains below the Rayleigh limit and beyond the reach of conventional microscopes. Super-resolution techniques are typically based on the non-linear and stochastic response of fluorescent labels which can be toxic and interfere with cell function. In this paper we present, for the first time, imaging of live cells using sub-optical wavelength phonons. The axial imaging resolution of our system is determined by the acoustic wavelength (λa = λprobe/2n) and not on the NA of the optics allowing sub-optical wavelength acoustic sectioning of samples using the time of flight. The transverse resolution is currently limited to the optical spot size. The contrast mechanism is significantly determined by the mechanical properties of the cells and requires no additional contrast agent, stain or label to image the cell structure. The ability to breach the optical diffraction limit to image living cells acoustically promises to bring a new suite of imaging technologies to bear in answering exigent questions in cell biology and biomedicine.

X Demographics

X Demographics

The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Canada 1 1%
Unknown 79 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 27%
Researcher 15 18%
Student > Master 11 13%
Lecturer 5 6%
Professor 4 5%
Other 13 16%
Unknown 12 15%
Readers by discipline Count As %
Physics and Astronomy 21 26%
Engineering 16 20%
Biochemistry, Genetics and Molecular Biology 7 9%
Chemistry 7 9%
Agricultural and Biological Sciences 4 5%
Other 12 15%
Unknown 15 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 184. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2017.
All research outputs
#215,633
of 25,374,374 outputs
Outputs from Scientific Reports
#2,530
of 139,680 outputs
Outputs of similar age
#4,590
of 434,493 outputs
Outputs of similar age from Scientific Reports
#66
of 3,724 outputs
Altmetric has tracked 25,374,374 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 139,680 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 434,493 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 3,724 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.